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CCAAT/enhancer binding proteins in normal mammary development and breast cancer
  • Published Date:
    Apr 19 2002
  • Publisher's site:
  • Source:
    Breast Cancer Res. 4(3):113-121.
Filetype[PDF - 116.33 KB]

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  • Pubmed Central ID:
  • Description:
    CCAAT/enhancer binding proteins (C/EBPs) are a family of leucine zipper, transcription factors that bind to DNA as homodimers and heterodimers. They regulate cellular proliferation, differentiation and apoptosis in the mammary gland. Multiple protein isoforms, including truncated, dominant negatives, are generated by translation of the C/EBPbeta transcript or via proteolytic cleavage of the full-length C/EBPbeta protein. Gene deletion of individual C/EBP family members has demonstrated an essential role for C/EBPbeta in normal mammary development, while transgenic and overexpression studies provide evidence that the dominant-negative C/EBPbeta-liver-enriched inhibitory protein isoform induces proliferation in mammary epithelial cells. Mounting evidence suggests that alterations in the ratio of the C/EBPbeta-liver-enriched inhibitory protein isoform and the C/EBPbeta-liver-enriched activating protein isoform may play a role in the development of breast cancer. This review will consequently focus on C/EBP actions in normal mammary development and on the emerging data that supports a role in breast cancer.

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  • Funding:
    NCI P30/CI/NCPDCID CDC HHS/United States
    P50 CA88843/CA/NCI NIH HHS/United States
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