Rapid recovery from K current inactivation on membrane hyperpolarization in molluscan neurons
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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
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Rapid recovery from K current inactivation on membrane hyperpolarization in molluscan neurons

  • Dec 1984

  • Source: J Gen Physiol. 84(6):861-875.


English

Details:

  • Alternative Title:
    J Gen Physiol
  • Description:
    Recovery from K current inactivation was studied in molluscan neurons using two-microelectrode and internal perfusion voltage clamps. Experiments were designed to study the voltage-dependent delayed outward current (IK) without contamination from other K currents. The amount of recovery from inactivation and the rate of recovery increase dramatically when the membrane potential is made more negative. The time course of recovery at the resting potential, -40 mV, is well fit by a single exponential with a time constant of 24.5 s (n = 7). At more negative voltages, the time course is best fit by the sum of two exponentials with time constants at -90 mV of 1.7 and 9.8 s (n = 7). In unclamped cells, a short hyperpolarization can cause rapid recovery from inactivation that results in a shortening of the action potential duration. We conclude that there are two inactivated states of the channel and that the time constants for recovery from both states are voltage dependent. The results are discussed in terms of the multistate model for K channel gating that was developed by R. N. Aldrich (1981, Biophys. J., 36:519-532).
  • Subjects:
  • Source:
  • Pubmed ID:
    6097637
  • Pubmed Central ID:
    PMC2228767
  • Document Type:
  • Funding:
  • Volume:
    84
  • Issue:
    6
  • Collection(s):
  • Main Document Checksum:
  • Download URL:
  • File Type:
    Filetype[PDF-849.98 KB]

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