Dose-Response Analysis in Animal Studies: Prediction of Human Responses

Details

• Journal Article:
  Environ Health Perspect
• Personal Author:
  Alarie, Yves
• Description:
  An animal bioassay has been used to evaluate a series of airborne chemicals for their sensory irritating properties to the upper respiratory tract. Teh results obtained can be used to rank their potency. An attempt has been made to predict "safe" levels of exposure for humans on the basis of this short-term assay. A good correlation was obtained between the predicted "safe" levels of exposure and current Threshold Limit Values established for industrial exposures.
• Subjects:
  Air Pollutants Animals Dose-Response Relationship, Drug Humans Maximum Allowable Concentration Toxicology
• Keywords:
  NIOSH-Publication; NIOSH-Grant; Toxicology; Comparative-toxicology; Eye-irritants; Respiratory-irritants; Analytical-methods; Screening-methods; Dose-response
• Source:
  Environ Health Perspect. 42:9-13.
• Pubmed ID:
  7333265
• Pubmed Central ID:
  PMC1568799
• Document Type:
  Text
• Funding:
  OH-00367/OH/NIOSH CDC HHS/United States ; Grant-Number-R01-OH-00367
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  5 pdf pages
• Volume:
  42
• NIOSHTIC Number:
  nn:00125200
• CAS Registry Number:
  2-Chlorobenzylidenemalononitrile (CAS RN 2698-41-1) ; Acrolein (CAS RN 107-02-8) ; Ammonia (CAS RN 7664-41-7) ; Chlorine (CAS RN 7782-50-5) ; Chloropicrin (CAS RN 76-06-2) ; Ethanone, 1-phenyl-, monochloro deriv. (CAS RN 1341-24-8) ; Ethyl acetate (CAS RN 141-78-6) ; Formaldehyde (CAS RN 50-00-0) ; Hydrochloric acid (CAS RN 7647-01-0) ; Sulfur dioxide (CAS RN 7446-09-5) ; Toluene 2,4-diisocyanate (CAS RN 584-84-9)
• Federal Fiscal Year:
  1982
• Performing Organization:
  University of Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:871f4562678395dd02124f19fe2f467c95f89f31440bc438a07a80fb15310eb08582c644f36088167933e63309f71012898eeb1600417a9ad6b9c5de30649397
• Download URL:
  https://stacks.cdc.gov/view/cdc/30781/cdc_30781_DS1.pdf
• File Type:
  [PDF - 654.23 KB ]