Spermatotoxicity Associated with Acute and Subchronic Ethoxyethanol Treatment

Details

• Journal Article:
  Environmental Health Perspectives
• Personal Author:
  Zenick, Harold ; Oudiz, Deborah ; Niewenhuis, Robert J.
• Description:
  A study was conducted in rats (male and female Long-Evans-hooded- rats) on the effects of ethoxyethanol (110805) (EE) on sperm counts, shape, and motility. Initially, the baseline ejaculates in female genital tracts were evaluated. Two days after baseline evaluation, intubation for 5 consecutive days, and at the end of this period the animals were mated. Four, 7, 10, and 14 weeks after cessation of the treatment, the sperm obtained from ejaculates was evaluated. All animals were sacrificed at week 16. Although EE treatment did not change the copulatory behavior of the rats, it caused a significant decline in the sperm counts in all groups. By 7 weeks, animals in the two highest dose groups were unable to produce sperm, but some degree of recovery was evident 10 weeks after EE exposure. The proportion of abnormally shaped sperm increased significantly at 7 weeks after exposure. Some testicular lesions were noted histologically, and pachytene spermatocytes were seen to be the most sensitive germ cell population. In a modification of the study, animals were treated 5 days a week for 6 weeks, and their sperm samples were evaluated weekly. Except for the appearance of signs of systemic toxicity, the results were similar to those of the first study. The authors conclude that this study demonstrates the significant toxic effect of EE on the testes and the potential for recovery from this toxic insult. [Description provided by NIOSH]
• Subjects:
  Body Weight Cytology Ether Ethylene Glycols Glycols Hazardous Substances Occupational Health Organ Size Rats Safety Sexual Behavior, Animal Spermatogenesis Spermatozoa Sperm Count Sperm Motility Time Factors Urogenital Diseases Urogenital System

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• Keywords:
  NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Fertility; Reproductive-effects; Spermatogenesis; Spermatozoa; Glycols; Ethers; Cytopathology; Toxic-effects
• Source:
  Environ Health Perspect 1984 Aug; 57:225-231
• ISSN:
  0091-6765
• Pubmed ID:
  6499807
• Pubmed Central ID:
  PMC1568293
• Document Type:
  Text
• Funding:
  ES-07073/ES/NIEHS NIH HHS/United States ; R01-OH-01272/OH/NIOSH CDC HHS/United States
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  7 pdf pages
• Volume:
  57
• NIOSHTIC Number:
  nn:00170967
• Contact Point Address:
  Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, Ohio 45267
• CAS Registry Number:
  Glycol monoethyl ether (CAS RN 110-80-5)
• Federal Fiscal Year:
  1984
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:c3867ca0ce07bc29c62fe43c8e969eaafce3a865ad7d1d3152524aafdbc03bca23a083cabb9c188350012fba9b179d692815e97bf7e3c75a034c72f7792a44b2
• Download URL:
  https://stacks.cdc.gov/view/cdc/30775/cdc_30775_DS1.pdf
• File Type:
  [PDF - 1.48 MB ]