DLC-1:a Rho GTPase-activating protein and tumour suppressor

Durkin, Marian E; Yuan, Bao-Zhu; Zhou, Xiaoling; Zimonjic, Drazen B; Lowy, Douglas R; Thorgeirsson, Snorri S; Popescu, Nicholas C

doi:10.1111/j.1582-4934.2007.00098.x

i

DLC-1:a Rho GTPase-activating protein and tumour suppressor

Supporting Files Public Domain

2007 Sep-Oct
By Durkin, Marian E ; Yuan, Bao-Zhu ; Zhou, Xiaoling ; ...

File Language:

English

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Alternative Title:

J Cell Mol Med
Personal Author:

Durkin, Marian E ; Yuan, Bao-Zhu ; Zhou, Xiaoling ; Zimonjic, Drazen B ; Lowy, Douglas R ; Thorgeirsson, Snorri S ; Popescu, Nicholas C
Description:

The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia.
Subjects:

Amino Acid Sequence Animals Cancer Detection Cancer Therapy Cytoskeletal Organization Deleted In Liver Cancer Focal Adhesion GTPase-Activating Proteins GTPase Activating Protein Humans Metastasis Suppressor Molecular Sequence Data Neoplasms Protein Structure, Tertiary Special Review Article Tensin Tumor Suppressor Proteins Tumour Suppressor
Source:

J Cell Mol Med. 11(5):1185-1207.
Document Type:

Journal Article
Volume:

11
Issue:

5
NIOSHTIC Number:

nn:20032902
Collection(s):

CDC Public Access National Institute for Occupational Safety and Health
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urn:sha-512:fa7b8409b7ef462817fbdaf5b069da050fd3e6f8c93f5fe8d4f545a0099e277d8294fbd1945480ef9369f009ea6e297b6bcfc9203ad7c5f92af5790c9110ff9b
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