DLC-1:A Rho GTPase-Activating Protein and Tumour Suppressor

Details

• Journal Article:
  Journal of Cellular and Molecular Medicine
• Personal Author:
  Durkin, Marian E. ; Yuan, Bao-Zhu ; Zhou, Xiaoling ; Zimonjic, Drazen B. ; Lowy, Douglas R. ; Thorgeirsson, Snorri S. ; Popescu, Nicholas C.
• Description:
  The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia. [Description provided by NIOSH]
• Subjects:
  Amino Acid Sequence Animals Biological Factors Carcinogens GTPase-Activating Proteins Liver Molecular Sequence Data Neoplasms Occupational Health Protein Structure, Tertiary Safety Teratogenesis Tumor Suppressor Proteins Urogenital Diseases Urogenital System

  More +
• Keywords:
  Proteins; Cell-growth; Tumorigenesis; Tumors; Tumorigens; Liver-cancer; Teratogenesis; Teratology; Biological-function; Biological-systems; Biological-effects; Biological-factors; Prostate-cancer
• Source:
  J Cell Mol Med 2007 Sep-Oct; 11(5):1185-1207
• ISSN:
  1582-1838
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  23 pdf pages
• Volume:
  11
• Issue:
  5
• NIOSHTIC Number:
  nn:20032902
• Contact Point Address:
  Nicholas C. Popescu, Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 37, Room 4128, 37 Convent Drive, MSC 4262, Bethesda, MD 20892-4262
• Email:
  popescun@mail.nih.gov
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:fa7b8409b7ef462817fbdaf5b069da050fd3e6f8c93f5fe8d4f545a0099e277d8294fbd1945480ef9369f009ea6e297b6bcfc9203ad7c5f92af5790c9110ff9b
• Download URL:
  https://stacks.cdc.gov/view/cdc/30612/cdc_30612_DS1.pdf
• File Type:
  [PDF - 655.91 KB ]