Association between Baseline Fetal Hemoglobin Levels and Incidence of Severe Vaso-Occlusive Pain Episodes in Children with Sickle Cell Anemia

Details

• Alternative Title:
  Pediatr Blood Cancer
• Personal Author:
  Bhatnagar, Pallav ; Keefer, Jeffrey R. ; Casella, James F. ; Barron-Casella, Emily A. ; Bean, Christopher J. ; Hooper, Craig W. ; Payne, Amanda B. ; Arking, Dan E. ; DeBaun, Michael R.
• Description:
  The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well-known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta-analysis of data from the Silent Infarct Transfusion Trial (n = 456) and the Cooperative Study of Sickle Cell Disease (n = 764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization (P-value = 0.02).
• Subjects:
  Adolescent Anemia, Sickle Cell Article Child Child, Preschool Constriction, Pathologic Female Fetal Hemoglobin Follow-Up Studies Humans Male Pain Sickle Cell Anemia Vaso-occlusive Pain

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• Source:
  Pediatr Blood Cancer. 60(10):E125-E127.
• Pubmed ID:
  23677903
• Pubmed Central ID:
  PMC4387562
• Document Type:
  Journal Article
• Funding:
  5R01HL091759/HL/NHLBI NIH HHS/United States ; 5U01-NS042804-03/NS/NINDS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; U54HL090515/HL/NHLBI NIH HHS/United States
• Volume:
  60
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:391e17e86b2ba52b36dc1adc344a47e1b9843eadd18ac2540a1e824808615e8d
• Download URL:
  https://stacks.cdc.gov/view/cdc/30365/cdc_30365_DS1.pdf
• File Type:
  [PDF - 121.52 KB ]