Menstrual Cycle Changes in Women with Inflammatory Bowel Disease: A Study from the Ocean State Crohn's and Colitis Area Registry
Published Date:Mar 2014
Source:Inflamm Bowel Dis. 20(3):534-540.
Pubmed Central ID:PMC4347838
Funding:1 UO1 DP000340-03/DP/NCCDPHP CDC HHS/United States
1R21DK078555-01/DK/NIDDK NIH HHS/United States
K12 HD055894/HD/NICHD NIH HHS/United States
K12HD055894/HD/NICHD NIH HHS/United States
R21 DK078555/DK/NIDDK NIH HHS/United States
Description:Background and Aims
The effect of the inflammatory bowel diseases (IBD) on menstrual function is largely unknown. The aims of this study were to determine whether changes in menstrual function occur in the year prior to IBD diagnosis or in the initial years after diagnosis.
Women aged 18 and above in the Ocean State Crohn's and Colitis Area Registry with at least 2 years of follow-up were eligible for this study. All subjects were enrolled within 6 months of IBD diagnosis and followed prospectively. Menstrual cycle characteristics were retrospectively assessed. To assess for changes over time, general linear models for correlated data were used for continuous outcomes and generalized estimating equations were used for discrete outcomes.
121 subjects were studied. Twenty-five percent of subjects experienced a change in cycle interval in the year prior to IBD diagnosis and 21% experienced a change in duration of flow. Among women with dysmenorrhea, 40% experienced a change in the intensity of their menstrual pain and 31% experienced a change in its duration. Overall cycle regularity increased over time.. Quality of life (QOL) was significantly lower in women without regular cycles across all time points.
Changes in menstrual function occur frequently in the year prior to IBD diagnosis; therefore screening for menstrual irregularities should be considered in women with newly diagnosed IBD. Patients can be reassured that cycles typically become more regular over time.
You May Also Like: