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Development and Applications of CRISPR-Cas9 for Genome Engineering
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  1. CRISPR-Cas systems for genome editing, regulation and targeting
    Personal Author:
    Sander, Jeffry D.; Joung, J. Keith;
    Published:
    Mar 02 2014
    Source:
    Nat Biotechnol. 32(4):347-355.
    Description:
    Targeted genome editing using engineered nucleases has rapidly gone from being a niche technology to a mainstream method used by many biological researchers. This widespread adoption has been largely fueled by the emergence of the clustered, regularl...
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  2. Applications of CRISPR-Cas systems in neuroscience
    Personal Author:
    Heidenreich, Matthias; Zhang, Feng;
    Published:
    Dec 10 2015
    Source:
    Nat Rev Neurosci. 17(1):36-44.
    Description:
    Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic in...
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  3. High-throughput functional genomics using CRISPR-Cas9
    Personal Author:
    Shalem, Ophir; Sanjana, Neville E.; Zhang, Feng;
    Published:
    Apr 09 2015
    Source:
    Nat Rev Genet. 2015; 16(5):299-311.
    Description:
    Forward genetic screens are powerful tools for the discovery and functional annotation of genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short palindromic repeat)-associated Cas9 nuclease has been combined with gen...
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  4. Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
    Personal Author:
    Bikard, David; Jiang, Wenyan; Samai, Poulami; Hochschild, Ann; Zhang, Feng; Marraffini, Luciano A.;
    Published:
    Jun 12 2013
    Source:
    Nucleic Acids Res. 2013; 41(15):7429-7437.
    Description:
    The ability to artificially control transcription is essential both to the study of gene function and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA-guided double-stranded DNA nuclease that participates in the ...
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    Filetype[PDF - 3.02 MB]
  5. In vivo genome editing using Staphylococcus aureus Cas9
    Personal Author:
    Ran, F. Ann; Cong, Le; Yan, Winston X.; Scott, David A.; Gootenberg, Jonathan S.; Kriz, Andrea J.; Zetsche, Bernd; Shalem, Ophir; Wu, Xuebing; Makarova, Kira S.; Koonin, Eugene; Sharp, Phillip A.; Zhang, Feng;
    Published:
    Apr 01 2015
    Source:
    Nature. 520(7546):186-191.
    Description:
    The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research and therapeutic applications that use the high...
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