Assisted hatching: trends and pregnancy outcomes, United States, 2000–2010

Details

• Alternative Title:
  Fertil Steril
• Personal Author:
  Kissin, Dmitry M. ; Kawwass, Jennifer F. ; Monsour, Michael ; Boulet, Sheree L. ; Session, Donna R. ; Jamieson, Denise J.
• Description:
  Objective
  
  To assess trends and outcomes of assisted hatching among assisted reproductive technology (ART) cycles.
  
  Design
  
  Retrospective cohort analysis using National ART Surveillance System (NASS) data.
  
  Setting
  
  U.S. fertility centers reporting to NASS.
  
  Patient(s)
  
  Fresh autologous noncanceled ART cycles conducted from 2000–2010.
  
  Intervention(s)
  
  None.
  
  Main Outcome Measure(s)
  
  Implantation, clinical pregnancy, live-birth, miscarriage, multiple gestation.
  
  Result(s)
  
  Assisted hatching use statistically significantly increased in absolute number (from 25,724 to 35,518 cycles), percentages of day-3 (from 50.7% to 56.3%) and day-5 transfers (from 15.9% to 22.8%), and percentage of transfers among women ≥38 years (from 17.8% to 21.8%) or women with ≥2 prior ART cycles and no live birth(s) (from 4.3% to 7.4%). Both day-3 and day-5 cycles involving assisted hatching were associated with lower odds of implantation (adjusted odds ratios [aOR] 0.7 and 0.6, respectively), clinical pregnancy (aOR 0.8 and 0.7, respectively), live birth (aOR 0.8 and 0.7, respectively), and increased odds of miscarriage (aOR 1.4 and 1.4, respectively), as compared with cycles without assisted hatching. Assisted hatching was associated with lower odds of multiple gestation in day-5 cycles (aOR 0.8). In cycles for women with a “poor prognosis,” the association of assisted hatching with pregnancy outcomes was not statistically significant.
  
  Conclusion(s)
  
  Assisted hatching use had an increasing trend but was not associated with improved pregnancy outcomes, even in poor-prognosis patients. Prospective studies are needed to identify the patients who may benefit from assisted hatching.
  
  
• Subjects:
  Adult Article Assisted Hatching Assisted Reproductive Technology (ART) Embryo Culture Techniques Embryo Transfer Female Fertilization In Vitro Humans In Vitro Fertilization (IVF) Live Birth Rate Pregnancy Pregnancy Outcome Pregnancy Rate Reproductive Techniques, Assisted United States Young Adult

  More +
• Source:
  Fertil Steril. 2014; 102(3):795-801
• Pubmed ID:
  25044084
• Pubmed Central ID:
  PMC4307791
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  102
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:89bd058e430c5ae17d6d6812b0b248118bdf2e12eaa8b24580089dbb251e898ea81192a9cb2e4b1fc9e7eb52ccadcc6e4c4d54452b3e7bb471d824cb79c5b521
• Download URL:
  https://stacks.cdc.gov/view/cdc/30266/cdc_30266_DS1.pdf
• File Type:
  [PDF - 384.68 KB ]