Racial/Ethnic Differences in Cancer Risk After Kidney Transplantation

Details

• Alternative Title:
  Am J Transplant
• Personal Author:
  Hall, EC ; Segev, DL ; Engels, EA
• Description:
  Transplant recipients have elevated cancer risk, but it is unknown if cancer risk differs across race and ethnicity as in the general population. US kidney recipients (N = 87,895) in the Transplant Cancer Match Study between 1992 and 2008 were evaluated for racial/ethnic differences in risk for six common cancers after transplantation. Compared to white recipients, black recipients had lower incidence of non-Hodgkin lymphoma (NHL) (adjusted incidence rate ratio [aIRR] 0.60, p<0.001) and higher incidence of kidney (aIRR 2.09, p<0.001) and prostate cancer (aIRR 2.14, p<0.001); Hispanic recipients had lower incidence of NHL (aIRR 0.64, p = 0.001), lung (aIRR 0.41, p < 0.001), breast (aIRR 0.53, p = 0.003) and prostate cancer (aIRR 0.72, p = 0.05). Colorectal cancer incidence was similar across groups. Standardized incidence ratios (SIRs) measured the effect of transplantation on cancer risk and were similar for most cancers (p≥0.1). However, black and Hispanic recipients had larger increases in kidney cancer risk with transplantation (SIRs: 8.96 in blacks, 5.95 in Hispanics vs. 4.44 in whites), and only blacks had elevated prostate cancer risk following transplantation (SIR: 1.21). Racial/ethnic differences in cancer risk after transplantation mirror general population patterns, except for kidney and prostate cancers where differences reflect the effects of end-stage renal disease or transplantation.
• Subjects:
  Adolescent Adult Black Or African American Child Child, Preschool Female Follow-Up Studies Hispanic Or Latino Humans Incidence Infant Infant, Newborn Kidney Diseases Kidney Transplantation Male Middle Aged Neoplasms Prognosis Registries Risk Factors White People Young Adult

  More +
• Source:
  Am J Transplant. 13(3):714-720.
• Document Type:
  Journal Article
• Funding:
  1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; 5658DP000805-04/DP/NCCDPHP CDC HHS/United States ; 5U58/DP000808-05/DP/NCCDPHP CDC HHS/United States ; 5U58DP000812-03/DP/NCCDPHP CDC HHS/United States ; 5U58DP000817-05/DP/NCCDPHP CDC HHS/United States ; 5U58DP000824-04/DP/NCCDPHP CDC HHS/United States ; HHSH234200537009C/PHS HHS/United States ; HHSH250201000018C/PHS HHS/United States ; HHSN261201000024C/PHS HHS/United States ; HHSN261201000026C/PHS HHS/United States ; HHSN261201000027C/PHS HHS/United States ; HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000036C/PHS HHS/United States ; HHSN261201000037C/PHS HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; N01-PC-35139/PC/NCI NIH HHS/United States ; N01-PC-35142/PC/NCI NIH HHS/United States ; N01-PC-35143/PC/NCI NIH HHS/United States ; N01-PC-54405/PC/NCI NIH HHS/United States ; T32 CA126607/CA/NCI NIH HHS/United States ; T32CA126607/CA/NCI NIH HHS/United States ; U58 DP000848-04/DP/NCCDPHP CDC HHS/United States ; U58DP000832/DP/NCCDPHP CDC HHS/United States ; Z01 CP010150-08/Intramural NIH HHS/United States
• Volume:
  13
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8201fedcfb183f2b26ca8a9b7cb53fe4a76197850e620a40af559302a910e751
• Download URL:
  https://stacks.cdc.gov/view/cdc/30183/cdc_30183_DS1.pdf
• File Type:
  [PDF - 137.64 KB ]