Welcome to CDC Stacks | Antineoplastic Drug Exposure in an Ambulatory Setting: a Pilot Study - 30176 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Antineoplastic Drug Exposure in an Ambulatory Setting: a Pilot Study
Filetype[PDF - 178.07 KB]


Details:
  • Pubmed ID:
    24831047
  • Pubmed Central ID:
    PMC4232489
  • Funding:
    P30CA46592/CA/NCI NIH HHS/United States
    R00 NR010750/NR/NINR NIH HHS/United States
    R00NR010750/NR/NINR NIH HHS/United States
    T42OH008455/OH/NIOSH CDC HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    Background

    Exposure to antineoplastic drugs confers health risks to workers, yet little is known about the exposure after a drug spill. Nor has the relationship between exposure and organizational factors such as staffing and work environment been studied.

    Objective

    To evaluate drug spills prospectively using biological measures and correlate drug spills with organizational factors.

    Methods

    Prospective questionnaires with 8-hour timed urine samples were collected from nursing and pharmacy personnel who reported a drug spill in one academic health center's infusion center. Urine was collected similarly from workers who did not report a spill. Liquid chromatography tandem mass spectrometry techniques identified detectable drug levels. After the prospective sampling period, workers were surveyed on workloads, practice environment, and safety behaviors.

    Results

    From 81 eligible individuals, 40 participated in the prospective study and 19 completed retrospective questionnaires. Four spills were reported by 9 personnel as multiple employees were exposed to drug spills. Four participants who reported a spill showed detectable levels of antineoplastic drugs. Four participants who did not report a spill had detectable levels of docetaxel. Compared with respondents who did not report a spill, collegial relations with physicians were significantly poorer for workers who reported spills.

    Conclusions

    The study protocol successfully captured drug spill reports and biological samples. Workers have detectable levels of antineoplastic drugs through both drug spills and environmental contamination.