Details:

Alternative Title:
Cancer Nurs
Publisher's site:
http://dx.doi.org/10.1097/NCC.0000000000000143
Personal Author:
Friese, Christopher R. ; McArdle, Cristin ; Zhau, Ting ; Sun, Duxin ; Spasojevic, Ivan ; ... More +
Friese, Christopher R. ; McArdle, Cristin ; Zhau, Ting ; Sun, Duxin ; Spasojevic, Ivan ; Polovich, Martha ; McCullagh, Marjorie C. Less -
Description:
Background

Exposure to antineoplastic drugs confers health risks to workers, yet little is known about the exposure after a drug spill. Nor has the relationship between exposure and organizational factors such as staffing and work environment been studied.

Objective

To evaluate drug spills prospectively using biological measures and correlate drug spills with organizational factors.

Methods

Prospective questionnaires with 8-hour timed urine samples were collected from nursing and pharmacy personnel who reported a drug spill in one academic health center's infusion center. Urine was collected similarly from workers who did not report a spill. Liquid chromatography tandem mass spectrometry techniques identified detectable drug levels. After the prospective sampling period, workers were surveyed on workloads, practice environment, and safety behaviors.

Results

From 81 eligible individuals, 40 participated in the prospective study and 19 completed retrospective questionnaires. Four spills were reported by 9 personnel as multiple employees were exposed to drug spills. Four participants who reported a spill showed detectable levels of antineoplastic drugs. Four participants who did not report a spill had detectable levels of docetaxel. Compared with respondents who did not report a spill, collegial relations with physicians were significantly poorer for workers who reported spills.

Conclusions

The study protocol successfully captured drug spill reports and biological samples. Workers have detectable levels of antineoplastic drugs through both drug spills and environmental contamination.


Subject:
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Article

Source:
Cancer Nurs. 38(2):111-117.
Pubmed ID:
24831047
Pubmed Central ID:
PMC4232489
Document Type:
Journal Article
Funding:
P30CA46592/CA/NCI NIH HHS/United States ; R00 NR010750/NR/NINR NIH HHS/United States ; R00NR010750/NR/NINR NIH HHS/United States ; T42OH008455/OH/NIOSH CDC HHS/United States
P30CA46592/CA/NCI NIH HHS/United States ; R00 NR010750/NR/NINR NIH HHS/United States ; R00NR010750/NR/NINR NIH HHS/United States ; T42OH008455/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0398abc96a70f0d8d00ca72e69c63b68218d00b2b031cb75fe739ae75829859b
File Type:

Supporting Files

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