Amplitude-masked photoacoustic wavefront shaping and application in flowmetry

Details

• Alternative Title:
  Opt Lett
• Personal Author:
  Tay, Jian Wei ; Liang, Jinyang ; Wang, Lihong V.
• Description:
  Optical-resolution photoacoustic flowmetry (PAF) allows noninvasive single-cell flow measurements. However, its operational depth is limited by optical diffusion, which prevents focusing beyond shallow depths in scattering media, as well as reducing the measurement signal-to-noise ratio (SNR). To overcome this limitation, we used binary-amplitude wavefront shaping to enhance light focusing in the presence of scattering. Here, the transmission modes that contributed constructively to the intensity at the optical focus were identified and selectively illuminated, resulting in a 14-fold intensity increase and a corresponding increase in SNR. This technique can potentially extend the operational depth of optical-resolution PAF beyond 1 mm in tissue.
• Keywords:
  Diffusion Photoacoustic Techniques Rheology
• Source:
  Opt Lett. 2014; 39(19):5499-5502
• Pubmed ID:
  25360912
• Pubmed Central ID:
  PMC4217128
• Document Type:
  Journal Article
• Funding:
  R01CA157277/CA/NCI NIH HHSUnited States/ ; R01 CA157277/CA/NCI NIH HHSUnited States/ ; R01 CA159959/CA/NCI NIH HHSUnited States/ ; R01 CA186567/CA/NCI NIH HHSUnited States/ ; DP1 EB016986/EB/NIBIB NIH HHSUnited States/ ; DP1 EB016986/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  39
• Issue:
  19
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:bc82c953c05ee800d24a8361fda261df75e99bfae6e9ac656cdbf3ecafabf81e
• Download URL:
  https://stacks.cdc.gov/view/cdc/30162/cdc_30162_DS1.pdf
• File Type:
  [PDF - 896.97 KB ]