Details:

Alternative Title:
Opt Lett
Personal Author:
Tay, Jian Wei ; Liang, Jinyang ; Wang, Lihong V.
Tay, Jian Wei ; Liang, Jinyang ; Wang, Lihong V. Less -
Description:
Optical-resolution photoacoustic flowmetry (PAF) allows noninvasive single-cell flow measurements. However, its operational depth is limited by optical diffusion, which prevents focusing beyond shallow depths in scattering media, as well as reducing the measurement signal-to-noise ratio (SNR). To overcome this limitation, we used binary-amplitude wavefront shaping to enhance light focusing in the presence of scattering. Here, the transmission modes that contributed constructively to the intensity at the optical focus were identified and selectively illuminated, resulting in a 14-fold intensity increase and a corresponding increase in SNR. This technique can potentially extend the operational depth of optical-resolution PAF beyond 1 mm in tissue.
Subject:
[+]
Article
Diffusion
Photoacoustic Techniques
Rheology

Source:
Opt Lett. 2014; 39(19):5499-5502.
Pubmed ID:
25360912
Pubmed Central ID:
PMC4217128
Document Type:
Journal Article
Funding:
R01CA157277/CA/NCI NIH HHS/United States ; R01 CA157277/CA/NCI NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; R01 CA186567/CA/NCI NIH HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; ... More +
R01CA157277/CA/NCI NIH HHS/United States ; R01 CA157277/CA/NCI NIH HHS/United States ; R01 CA159959/CA/NCI NIH HHS/United States ; R01 CA186567/CA/NCI NIH HHS/United States ; DP1 EB016986/EB/NIBIB NIH HHS/United States ; DP1 EB016986/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:bc82c953c05ee800d24a8361fda261df75e99bfae6e9ac656cdbf3ecafabf81e
File Type:

Supporting Files

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