Details:

Alternative Title:
Small
Personal Author:
Yin, Perry T. ; Shah, Birju P. ; Lee, Ki-Bum
Yin, Perry T. ; Shah, Birju P. ; Lee, Ki-Bum Less -
Description:
A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells.
Subjects:
[+]
Apoptosis Article Brain Neoplasms Drug Delivery Glioblastoma Humans Hyperthermia Hyperthermia, Induced Magnetic Nanoparticles Magnetics MicroRNA MicroRNAs Nanoparticles Nanotechnology
Source:
Small. 10(20):4106-4112
Pubmed ID:
24947843
Pubmed Central ID:
PMC4206574
Document Type:
Journal Article
Funding:
DP2 OD006462/OD/NIH HHS/United States ; R21 NS085569/NS/NINDS NIH HHS/United States ; T32 GM008339/GM/NIGMS NIH HHS/United States ; 1DP20D006462-01/DP/NCCDPHP CDC HHS/United States
DP2 OD006462/OD/NIH HHS/United States ; R21 NS085569/NS/NINDS NIH HHS/United States ; T32 GM008339/GM/NIGMS NIH HHS/United States ; 1DP20D006462-01/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e598b964dfc25139d297fb228f5b98b3fbb8f340b926be9e1b1d910246533dc7
Download URL:
https://stacks.cdc.gov/view/cdc/30152/cdc_30152_DS1.pdf
File Type:

Supporting Files

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  	NIHMS608116-supplement-01.pdf	pdf
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