Combined magnetic nanoparticle-based microRNA and hyperthermia therapy to enhance apoptosis in brain cancer cells

Details

• Alternative Title:
  Small
• Personal Author:
  Yin, Perry T. ; Shah, Birju P. ; Lee, Ki-Bum
• Description:
  A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells.
• Subjects:
  Apoptosis Article Brain Neoplasms Drug Delivery Glioblastoma Humans Hyperthermia Hyperthermia, Induced Magnetic Nanoparticles Magnetics MicroRNA MicroRNAs Nanoparticles Nanotechnology

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• Source:
  Small. 10(20):4106-4112
• Pubmed ID:
  24947843
• Pubmed Central ID:
  PMC4206574
• Document Type:
  Journal Article
• Funding:
  DP2 OD006462/OD/NIH HHS/United States ; R21 NS085569/NS/NINDS NIH HHS/United States ; T32 GM008339/GM/NIGMS NIH HHS/United States ; 1DP20D006462-01/DP/NCCDPHP CDC HHS/United States
• Volume:
  10
• Issue:
  20
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:1a41fdcc1b57b2e7bd7f922bfda18f2dbbd43c6379154e8cc3468fed22b7012bb6062fd3ae734786ae9f03e3ed09d6f77e97f73e0e0eaa763a6ad9af6b23a31c
• Download URL:
  https://stacks.cdc.gov/view/cdc/30152/cdc_30152_DS1.pdf
• File Type:
  [PDF - 662.26 KB ]