Sequential Gene Silencing Using Wavelength-Selective Caged Morpholinos**

Yamazoe, Sayumi; Liu, Qingyang; McQuade, Lindsey E.; Deiters, Alexander; Chen, James K.

doi:10.1002/anie.201405355

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Sequential Gene Silencing Using Wavelength-Selective Caged Morpholinos**

Published Date:

Aug 01 2014

Publisher's site:

http://dx.doi.org/10.1002/anie.201405355

Source:

Angew Chem Int Ed Engl. 2013; 53(38):10114-10118.

[PDF-795.37 KB]

Details:

Alternative Title:

Angew Chem Int Ed Engl

Personal Author:

Yamazoe, Sayumi ; Liu, Qingyang ; McQuade, Lindsey E. ; Deiters, Alexander ; Chen, James K. ;

Description:

Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength-selective illumination have been used to sequentially inactivate organismal gene function. The efficacy of these reverse-genetic chemical probes has been demonstrated in zebrafish embryos, and these reagents have been employed to examine the mechanisms of mesoderm patterning.

Subject:

[+]

Pubmed ID:

25130695

Pubmed Central ID:

PMC4206551

Document Type:

Journal Article

Funding:

DP1 HD075622/DP/NCCDPHP CDC HHS/United States ; P50 GM107615/GM/NIGMS NIH HHS/United States ; R01 GM079114/GM/NIGMS NIH HHS/United States ; R01 GM079114/GM/NIGMS NIH HHS/United States ; R01 GM087292/GM/NIGMS NIH HHS/United States ; ... More ▼

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

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Sequential Gene Silencing Using Wavelength-Selective Caged Morpholinos**

Sequential Gene Silencing Using Wavelength-Selective Caged Morpholinos**

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