Details:

Alternative Title:
Cancer Invest
Publisher's site:
http://dx.doi.org/10.3109/07357907.2014.919305
Personal Author:
Wirth, Michael D. ; Burch, James B. ; Hébert, James R. ; Kowtal, Pradnya ; Kapoor, Aparna ; ... More +
Wirth, Michael D. ; Burch, James B. ; Hébert, James R. ; Kowtal, Pradnya ; Kapoor, Aparna ; Steck, Susan E. ; Hurley, Thomas G. ; Gupta, Prakash C. ; Pednekar, Mangesh S. ; Youngstedt, Shawn D. ; Zhang, Hongmei ; Sarin, Rajiv Less -
Description:
Background

This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women.

Methods

This case-control study included sporadic, histologically confirmed BrCA cases (n=255) and controls (n=249) from India with data collection from 2010–2012.

Results

Women with the 4/5 or 5/5 PER3 genotype had a non-statistically significant 33% increased odds of BrCA. BrCA cases were more likely to have a morning (OR=2.43, 95% CI=1.23–4.81) or evening (OR=2.55, 95% CI=1.19–5.47) chronotype.

Conclusions

Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in adverse health outcomes.


Subjects:
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Adult Aged Article Breast Neoplasms Case-Control Studies Circadian Rhythm Female Humans India Middle Aged Nuclear Proteins Period Circadian Proteins Polymorphism, Genetic Risk Factors Surveys And Questionnaires Tandem Repeat Sequences
Source:
Cancer Invest. 32(7):321-329
Pubmed ID:
24903750
Pubmed Central ID:
PMC4100474
Document Type:
Journal Article
Funding:
K05 CA136975/CA/NCI NIH HHSUnited States/ ; T32 GM081740/GM/NIGMS NIH HHSUnited States/ ; K05CA136975/CA/NCI NIH HHSUnited States/ ; T32-5R18CE001240/CE/NCIPC CDC HHSUnited States/
K05 CA136975/CA/NCI NIH HHSUnited States/ ; T32 GM081740/GM/NIGMS NIH HHSUnited States/ ; K05CA136975/CA/NCI NIH HHSUnited States/ ; T32-5R18CE001240/CE/NCIPC CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:bdff7ad7c478db2d010bff8c0e5fc446310902b87de7dfd61b69c3ab264186db
Download URL:
https://stacks.cdc.gov/view/cdc/30037/cdc_30037_DS1.pdf
File Type:

Supporting Files

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