Case-Control Study of Breast Cancer in India: Role of PERIOD3 Clock Gene Length Polymorphism and Chronotype
Published Date:Jun 06 2014
Source:Cancer Invest. 32(7):321-329.
Pubmed Central ID:PMC4100474
Funding:K05 CA136975/CA/NCI NIH HHS/United States
K05CA136975/CA/NCI NIH HHS/United States
T32 GM081740/GM/NIGMS NIH HHS/United States
T32-5R18CE001240/CE/NCIPC CDC HHS/United States
This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women.
This case-control study included sporadic, histologically confirmed BrCA cases (n=255) and controls (n=249) from India with data collection from 2010–2012.
Women with the 4/5 or 5/5 PER3 genotype had a non-statistically significant 33% increased odds of BrCA. BrCA cases were more likely to have a morning (OR=2.43, 95% CI=1.23–4.81) or evening (OR=2.55, 95% CI=1.19–5.47) chronotype.
Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in adverse health outcomes.
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