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Case-Control Study of Breast Cancer in India: Role of PERIOD3 Clock Gene Length Polymorphism and Chronotype
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8 2014
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Source: Cancer Invest. 32(7):321-329
[PDF-342.95 KB]
Details:
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Alternative Title:Cancer Invest
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Personal Author:
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Description:Background
This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women.
Methods
This case-control study included sporadic, histologically confirmed BrCA cases (n=255) and controls (n=249) from India with data collection from 2010–2012.
Results
Women with the 4/5 or 5/5 PER3 genotype had a non-statistically significant 33% increased odds of BrCA. BrCA cases were more likely to have a morning (OR=2.43, 95% CI=1.23–4.81) or evening (OR=2.55, 95% CI=1.19–5.47) chronotype.
Conclusions
Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in adverse health outcomes.
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Pubmed ID:24903750
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Pubmed Central ID:PMC4100474
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Volume:32
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Issue:7
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