Details:

Alternative Title:
Paediatr Perinat Epidemiol
Publisher's site:
http://dx.doi.org/10.1111/ppe.12123
Personal Author:
Carmichael, Suzan L. ; Ma, Chen ; Tinker, Sarah ; Rasmussen, Sonja A. ; Shaw, Gary M.
Carmichael, Suzan L. ; Ma, Chen ; Tinker, Sarah ; Rasmussen, Sonja A. ; Shaw, Gary M. Less -
Corporate Authors:
National Birth Defects Prevention Study
Description:
Background

We examined the association of maternal stressful life events and social support with risks of birth defects using National Birth Defects Prevention Study data, a population-based case-control study.

Methods

We examined 7 stressful life events and 3 social support questions applicable to the periconceptional period, among mothers of 552 cases with neural tube defects (NTDs), 413 cleft palate (CP), 797 cleft lip +/− cleft palate (CLP), 189 d-transposition of the great arteries (dTGA), 311 tetralogy of Fallot (TOF), and 2,974 non-malformed controls. A stressful life events index equaled the sum of “yes” responses to the 7 questions. Social support questions were also summed to form an index. Data were analyzed using logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), adjusted for maternal race-ethnicity, age, education, body mass index, smoking, drinking, and intake of vitamin supplements.

Results

Associations with the stress index tended to be higher with higher scores, but few 95% CIs excluded one. A 4-point increase in the index was moderately associated with NTDs (OR 1.5, 95% CI 1.1, 2.0) and CLP (OR 1.3, 95% CI 1.0–1.7). The social support index tended to be associated with reduced risk but most 95% CIs included one, with the exception of dTGA (OR for a score of three versus zero was 0.5, 95% CI 0.3–0.8).

Conclusions

Maternal periconceptional stressful life events, social support, and the two factors in combination were at most modestly, if at all, associated with risks of the studied birth defects.


Subjects:
[+]
Adult Body Mass Index Case-Control Studies Congenital Abnormalities Educational Status Female Humans Infant Life Change Events Maternal Behavior Pregnancy Prenatal Care Prenatal Exposure Delayed Effects Questionnaires Risk Factors Social Support Stress, Psychological
Source:
Paediatr Perinat Epidemiol. 28(4):338-344.
Pubmed ID:
24697924
Pubmed Central ID:
PMC4057295
Document Type:
Journal Article
Funding:
1U01-DD-0006982/DD/NCBDD CDC HHS/United States ; CDC 6U01-DD-000489/DD/NCBDD CDC HHS/United States ; NIH R03 DE020112/DE/NIDCR NIH HHS/United States ; R03 DE020112/DE/NIDCR NIH HHS/United States
1U01-DD-0006982/DD/NCBDD CDC HHS/United States ; CDC 6U01-DD-000489/DD/NCBDD CDC HHS/United States ; NIH R03 DE020112/DE/NIDCR NIH HHS/United States ; R03 DE020112/DE/NIDCR NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:79cd753c86c28a1dda43a51844a9992be4b446dc93ba23e8e029e3313a8f0da3
Download URL:
https://stacks.cdc.gov/view/cdc/29997/cdc_29997_DS1.pdf
File Type:

Supporting Files

• 	NIHMS576743-supplement-supplement_1.pdf	pdf
  	nihms576743.nxml	txt

More +