Characteristics of abdominal vein thrombosis in children and adults

Landi, Daniel; Beckman, Michele G.; Shah, Nirmish R.; Bockenstedt, Paula; Grant, Althea M.; Heit, John A.; Key, Nigel S.; Kulkarni, Roshni; Manco-Johnson, Marilyn; Moll, Stephan; Philipp, Claire S.; Andersen, Judith C.; Ortel, Thomas L.

doi:10.1160/TH12-08-0568

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Characteristics of abdominal vein thrombosis in children and adults

Published Date:

Feb 14 2013

Publisher's site:

http://dx.doi.org/10.1160/TH12-08-0568 New Site Icon

Source:

Thromb Haemost. 2013; 109(4):625-632.

[PDF-310.66 KB]

Details:

Personal Authors:

Landi, Daniel ; Beckman, Michele G. ; Shah, Nirmish R. ; Bockenstedt, Paula ; Grant, Althea M. ; ... More ▼

Keywords:

[+]

Pubmed ID:

23407670

Pubmed Central ID:

PMC3963260

Description:

The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the setting of known disease might have prognostic implications different from LE DVT/PE. This study describes clinical presentations of abdominal VT compared to LE DVT/PE in adults and children. We analysed prospectively-collected data from consecutive consenting patients enrolled in one of seven Centers for Disease Control and Prevention (CDC) funded Thrombosis and Hemostasis Network Centers from August 2003 to April 2011 to compare the demographic and clinical characteristics of adults and children with abdominal VT. Both adults and children with abdominal VT tended to be younger and have a lower body mass index (BMI) than those with LE DVT/PE. Of patients with abdominal VT, children were more likely to have inferior vena cava (IVC) thrombosis than adults. For adults with venous thromboembolism (VTE), relatively more women had abdominal VT than LE DVT/PE, while the proportions with LE DVT/PE and abdominal VT by sex were similar in children. Children with abdominal VT were more likely to have diagnosed inherited thrombophilia, while trauma was more common in children with LE DVT/PE. In conclusion, both children and adults with abdominal VT were younger with a lower BMI than those with LE DVT/PE. Significant differences exist between children and adults in respect to abdominal VT compared to LE DVT/PE.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DD000016/DD/NCBDD CDC HHS/United States
U01 DD000014/DD/NCBDD CDC HHS/United States
DD000014/DD/NCBDD CDC HHS/United States
K12 HL087097/HL/NHLBI NIH HHS/United States
DD07-005/DD/NCBDD CDC HHS/United States
U18 DD000015/DD/NCBDD CDC HHS/United States
U01 DD000017/DD/NCBDD CDC HHS/United States
K12 HL 087097/HL/NHLBI NIH HHS/United States
DD000017/DD/NCBDD CDC HHS/United States
U18 DD000014/DD/NCBDD CDC HHS/United States
DD07-004/DD/NCBDD CDC HHS/United States
U01 DD000016/DD/NCBDD CDC HHS/United States
DD000015/DD/NCBDD CDC HHS/United States
U18 DD000017/DD/NCBDD CDC HHS/United States
U18 DD000016/DD/NCBDD CDC HHS/United States

Supporting Files:

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