Details:

Alternative Title:
Thromb Haemost
Publisher's site:
http://dx.doi.org/10.1160/TH12-08-0568
Personal Author:
Landi, Daniel; Beckman, Michele G.; Shah, Nirmish R.; Bockenstedt, Paula; Grant, Althea M.; ... More +
Landi, Daniel; Beckman, Michele G.; Shah, Nirmish R.; Bockenstedt, Paula; Grant, Althea M.; Heit, John A.; Key, Nigel S.; Kulkarni, Roshni; Manco-Johnson, Marilyn; Moll, Stephan; Philipp, Claire S.; Andersen, Judith C.; Ortel, Thomas L.; Less -
Description:
The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the setting of known disease might have prognostic implications different from LE DVT/PE. This study describes clinical presentations of abdominal VT compared to LE DVT/PE in adults and children. We analysed prospectively-collected data from consecutive consenting patients enrolled in one of seven Centers for Disease Control and Prevention (CDC) funded Thrombosis and Hemostasis Network Centers from August 2003 to April 2011 to compare the demographic and clinical characteristics of adults and children with abdominal VT. Both adults and children with abdominal VT tended to be younger and have a lower body mass index (BMI) than those with LE DVT/PE. Of patients with abdominal VT, children were more likely to have inferior vena cava (IVC) thrombosis than adults. For adults with venous thromboembolism (VTE), relatively more women had abdominal VT than LE DVT/PE, while the proportions with LE DVT/PE and abdominal VT by sex were similar in children. Children with abdominal VT were more likely to have diagnosed inherited thrombophilia, while trauma was more common in children with LE DVT/PE. In conclusion, both children and adults with abdominal VT were younger with a lower BMI than those with LE DVT/PE. Significant differences exist between children and adults in respect to abdominal VT compared to LE DVT/PE.
Subject:
[+]
Abdomen
Adolescent
Adult
Aged
Aged, 80 And Over
Age Distribution
Age Factors
Body Mass Index
Chi-Square Distribution
Child
Child, Preschool
Cross-Sectional Studies
Female
Genetic Predisposition To Disease
Humans
Infant
Infant, Newborn
Logistic Models
Lower Extremity
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Prevalence
Prognosis
Prospective Studies
Registries
Risk Factors
Sex Factors
Thrombophilia
Vena Cava, Inferior
Venous Thrombosis
Wounds And Injuries
Young Adult

Source:
Thromb Haemost. 2013; 109(4):625-632.;
Pubmed ID:
23407670
Pubmed Central ID:
PMC3963260
Document Type:
Journal Article;
Funding:
DD000016/DD/NCBDD CDC HHS/United States; U01 DD000014/DD/NCBDD CDC HHS/United States; DD000014/DD/NCBDD CDC HHS/United States; K12 HL087097/HL/NHLBI NIH HHS/United States; DD07-005/DD/NCBDD CDC HHS/United States; ... More +
DD000016/DD/NCBDD CDC HHS/United States; U01 DD000014/DD/NCBDD CDC HHS/United States; DD000014/DD/NCBDD CDC HHS/United States; K12 HL087097/HL/NHLBI NIH HHS/United States; DD07-005/DD/NCBDD CDC HHS/United States; U18 DD000015/DD/NCBDD CDC HHS/United States; U01 DD000017/DD/NCBDD CDC HHS/United States; K12 HL 087097/HL/NHLBI NIH HHS/United States; DD000017/DD/NCBDD CDC HHS/United States; U18 DD000014/DD/NCBDD CDC HHS/United States; DD07-004/DD/NCBDD CDC HHS/United States; U01 DD000016/DD/NCBDD CDC HHS/United States; DD000015/DD/NCBDD CDC HHS/United States; U18 DD000017/DD/NCBDD CDC HHS/United States; U18 DD000016/DD/NCBDD CDC HHS/United States; Less -
Place as Subject:
United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e1535b993dea94400f95f9841c7cefc670cff5766f52d3a44091edda5deda4c5
File Type:

Supporting Files

• 	nihms549219.nxml	xml
  	nihms549219f1.gif	gif
  	nihms549219f1.jpg	jpeg

More +