Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

Gao, Lizeng; Giglio, Krista M.; Nelson, Jacquelyn L.; Sondermann, Holger; Travis, Alexander J.

doi:10.1039/c3nr05422e

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

Published Date:

Jan 27 2014

Publisher's site:

http://dx.doi.org/10.1039/c3nr05422e New Site Icon

Source:

Nanoscale. 2012; 6(5):2588-2593.

[PDF-1.51 MB]

Details:

Personal Authors:

Gao, Lizeng ; Giglio, Krista M. ; Nelson, Jacquelyn L. ; Sondermann, Holger ; Travis, Alexander J. ;

Keywords:

[+]

Pubmed ID:

24468900

Pubmed Central ID:

PMC3951791

Description:

Hydrogen peroxide (H2O2) is a "green chemical" that has various cleaning and disinfectant uses, including as an anti-bacterial agent for hygienic and medical treatments. However, its efficacy is limited against biofilm-producing bacteria, because of poor penetration into the protective, organic matrix. Here we show new applications for ferromagnetic nanoparticles (Fe3O4, MNPs) with peroxidase-like activity in potentiating the efficacy of H2O2 in biofilm degradation and prevention. Our data show that MNPs enhanced oxidative cleavage of biofilm components (model nucleic acids, proteins, and oligosaccharides) in the presence of H2O2. When challenged with live, biofilm-producing bacteria, the MNP-H2O2 system efficiently broke down the existing biofilm and prevented new biofilms from forming, killing both planktonic bacteria and those within the biofilm. By enhancing oxidative cleavage of various substrates, the MNP-H2O2 system provides a novel strategy for biofilm elimination, and other applications utilizing oxidative breakdown.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

8DP1-EB016541/DP/NCCDPHP CDC HHS/United States
DP1 EB016541/EB/NIBIB NIH HHS/United States
R01 AI097307/AI/NIAID NIH HHS/United States

Supporting Files:

	nihms559679f4.gif	image/gif
	nihms559679f4.jpg	image/jpeg
	nihms559679f5.gif	image/gif
	nihms559679f5.jpg	image/jpeg
	nihms559679f6.gif	image/gif
	nihms559679f6.jpg	image/jpeg
	NIHMS559679-supplement-ESI.pdf	application/pdf
	nihms559679.nxml	text/plain
	nihms559679f1.gif	image/gif
	nihms559679f1.jpg	image/jpeg
	nihms559679f2.gif	image/gif
	nihms559679f2.jpg	image/jpeg
	nihms559679f3.gif	image/gif
	nihms559679f3.jpg	image/jpeg

No Related Documents.

You May Also Like:

Enzymatic Oxidative Biodegradation of Nanoparticles: Mechanisms, Significance and Applications

Personal Author:

Vlasova, Irina I.; Kapralov, Alexandr A.; Michael, Zachary P.; Burkert, Seth C.; Shurin, Michael R.; Star, Alexander; Shvedova, Anna A.; Kagan, Valerian E.;

Published:

Jan 06 2016

Source:

Toxicol Appl Pharmacol. 299:58-69.

Description:

Biopersistence of carbon nanotubes, graphene oxide (GO) and several other types of carbonaceous nanomaterials is an essential determinant of their health effects. Successful biodegradation is one of the major factors defining the life span and biolog...

File Type:

[PDF - 2.36 MB]
Molecular modeling in structural nano-toxicology: Interactions of nano-particles with nano-machinery of cells

Personal Author:

Yanamala, Naveena; Kagan, Valerian E.; Shvedova, Anna A.;

Published:

May 28 2013

Source:

Adv Drug Deliv Rev. 65(15):2070-2077.

Description:

Over the past two decades, nanotechnology has emerged as a key player in various disciplines of science and technology. Some of the most exciting applications are in the field of biomedicine - for theranostics (for combined diagnostic and therapeutic...

File Type:

[PDF - 1.37 MB]
Peroxidase-mediated Biodegradation of Carbon Nanotubes in vitro and in vivo

Personal Author:

Kotchey, Gregg P.; Zhao, Yong; Kagan, Valerian E.; Star, Alexander;

Published:

Jul 12 2013

Source:

Adv Drug Deliv Rev. 2013; 65(15):1921-1932.

Description:

As a result of their unique electronic, optical, and mechanical properties, carbon nanotubes (CNTs) have been implemented in therapeutic and imaging applications. In an idealized situation, CNTs would be disposed of after they transport their therano...

File Type:

[PDF - 1.12 MB]
Low Power Upconverted Near-IR Light for Efficient Polymeric Nanoparticle Degradation and Cargo Release

Personal Author:

Viger, Mathieu L.; Grossman, Madeleine; Fomina, Nadezda; Almutairi, Adah;

Published:

May 31 2013

Source:

Adv Mater. 25(27):3733-3738.

Description:

By encapsulating NaYF4 :Tm.Yb upconverting nanocrystals in UV-degradable polymer capsules, it is possible to access efficient polymer photodegradation and remotely controlled release using near-IR laser light at an unprecedentedly low power.

File Type:

[PDF - 1.37 MB]
Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling

Personal Author:

Apopa, Patrick L; Qian, Yong; Shao, Rong; Guo, Nancy Lan; Schwegler-Berry, Diane; Pacurari, Maricica; Porter, Dale; Shi, Xianglin; Vallyathan, Val; Castranova, Vincent; Flynn, Daniel C;

Published:

Jan 09 2009

Source:

Part Fibre Toxicol. 2009; 6:1.

Description:

Background : Engineered iron nanoparticles are being explored for the development of biomedical applications and many other industry purposes. However, to date little is known concerning the precise mechanisms of translocation of iron nanoparticles i...

File Type:

[PDF - 3.01 MB]