Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

Gao, Lizeng; Giglio, Krista M.; Nelson, Jacquelyn L.; Sondermann, Holger; Travis, Alexander J.

doi:10.1039/c3nr05422e

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Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

Published Date:

Jan 27 2014

Publisher's site:

http://dx.doi.org/10.1039/c3nr05422e

Source:

Nanoscale. 2012; 6(5):2588-2593.

[PDF-1.51 MB]

Details:

Alternative Title:

Nanoscale

Personal Author:

Gao, Lizeng ; Giglio, Krista M. ; Nelson, Jacquelyn L. ; Sondermann, Holger ; Travis, Alexander J. ;

Description:

Hydrogen peroxide (H2O2) is a "green chemical" that has various cleaning and disinfectant uses, including as an anti-bacterial agent for hygienic and medical treatments. However, its efficacy is limited against biofilm-producing bacteria, because of poor penetration into the protective, organic matrix. Here we show new applications for ferromagnetic nanoparticles (Fe3O4, MNPs) with peroxidase-like activity in potentiating the efficacy of H2O2 in biofilm degradation and prevention. Our data show that MNPs enhanced oxidative cleavage of biofilm components (model nucleic acids, proteins, and oligosaccharides) in the presence of H2O2. When challenged with live, biofilm-producing bacteria, the MNP-H2O2 system efficiently broke down the existing biofilm and prevented new biofilms from forming, killing both planktonic bacteria and those within the biofilm. By enhancing oxidative cleavage of various substrates, the MNP-H2O2 system provides a novel strategy for biofilm elimination, and other applications utilizing oxidative breakdown.

Subject:

[+]

Pubmed ID:

24468900

Pubmed Central ID:

PMC3951791

Document Type:

Journal Article

Funding:

8DP1-EB016541/DP/NCCDPHP CDC HHS/United States ; DP1 EB016541/EB/NIBIB NIH HHS/United States ; R01 AI097307/AI/NIAID NIH HHS/United States ;

Collection(s):

CDC Public Access

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Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

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