Body mass and smoking are modifiable risk factors for recurrent bladder cancer

Details

• Alternative Title:
  Cancer
• Personal Author:
  Wyszynski, Asaf ; Tanyos, Sam A. ; Rees, Judy R. ; Marsit, Carmen J. ; Kelsey, Karl T. ; Schned, Alan R. ; Pendleton, Eben M. ; Celaya, Maria O. ; Zens, Michael S. ; Karagas, Margaret R. ; Andrew, Angeline S.
• Description:
  Background
  
  In the Western world, bladder cancer is the fourth most common cancer in men and the eighth most common in women. Recurrences frequently occur and continued surveillance is necessary to identify and treat recurrent tumors. Efforts to identify risk factors that are potentially modifiable to reduce the rate of recurrence are needed.
  
  Methods
  
  We investigated cigarette smoking behavior and body mass index (BMI) at diagnosis for associations with bladder cancer recurrence in a population-based study of 726 bladder cancer patients in New Hampshire, US. Patients diagnosed with non-muscle invasive urothelial-cell carcinoma were followed to ascertain long-term prognosis. Analysis of time to recurrence was performed using multivariate Cox regression models.
  
  Results
  
  Smokers experienced shorter time to recurrence (continuing smoker HR 1.51 95%CI 1.08-2.13). Although being overweight (BMI>24.9 kg/m2) at diagnosis was not a strong independent factor (HR 1.33 95%CI 0.94-1.89), among continuing smokers, being overweight more than doubled the risk of recurrence compared to smokers of normal weight (HR 2.67 95%CI 1.14-6.28).
  
  Conclusions
  
  These observational results suggest that adiposity is a risk factor for bladder cancer recurrence, particularly among tobacco users. Future intervention studies are warranted to evaluate whether both smoking cessation and weight reduction strategies reduce bladder tumor recurrences.
  
  
• Subjects:
  Adiposity Adult Aged Article Bladder Cancer BMI Body Mass Index Female Humans Male Middle Aged Neoplasm Recurrence, Local Obesity Proportional Hazards Models Recurrence Risk Factors Smoking Urinary Bladder Neoplasms Urothelial-cell Carcinoma

  More +
• Source:
  Cancer. 120(3):408-414.
• Pubmed ID:
  24122218
• Pubmed Central ID:
  PMC3946933
• Document Type:
  Journal Article
• Funding:
  CA121382/CA/NCI NIH HHS/United States ; CA82354/CA/NCI NIH HHS/United States ; ES00002/ES/NIEHS NIH HHS/United States ; ES05947/ES/NIEHS NIH HHS/United States ; ES07373/ES/NIEHS NIH HHS/United States ; K07 CA102327/CA/NCI NIH HHS/United States ; K07CA102327/CA/NCI NIH HHS/United States ; P20 GM103534/GM/NIGMS NIH HHS/United States ; P20 RR018787/RR/NCRR NIH HHS/United States ; P20 RR024475/RR/NCRR NIH HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; P42 ES005947/ES/NIEHS NIH HHS/United States ; P42 ES007373/ES/NIEHS NIH HHS/United States ; R01 CA082354/CA/NCI NIH HHS/United States ; R03 CA121382/CA/NCI NIH HHS/United States ; R21 CA182659/CA/NCI NIH HHS/United States ; RR018787/RR/NCRR NIH HHS/United States ; U58/DP000798/DP/NCCDPHP CDC HHS/United States
• Volume:
  120
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c0aa8dd20d6a1339352ff8cf00cf5e32c3db0e43ca206690a12aac152fa5ae55
• Download URL:
  https://stacks.cdc.gov/view/cdc/29875/cdc_29875_DS1.pdf
• File Type:
  [PDF - 626.22 KB ]