Absolute Photoacoustic Thermometry in Deep Tissue

Details

• Alternative Title:
  Opt Lett
• Personal Author:
  Yao, Junjie ; Ke, Haixin ; Tai, Stephen ; Zhou, Yong ; Wang, Lihong V.
• Description:
  Photoacoustic thermography is a promising tool for temperature measurement in deep tissue. Here we propose an absolute temperature measurement method based on the dual temperature dependences of the Grüneisen parameter and the speed of sound in tissue. By taking ratiometric measurements at two adjacent temperatures, we can eliminate the factors that are temperature irrelevant but difficult to correct for in deep tissue. To validate our method, absolute temperatures of blood-filled tubes embedded ~9 mm deep in chicken tissue were measured in a biologically relevant range from 28°C to 46°C. The temperature measurement accuracy was ~0.6°C. The results suggest that our method can be potentially used for absolute temperature monitoring in deep tissue during thermotherapy.
• Subjects:
  Animals Article Mammary Glands, Animal Photoacoustic Techniques Sound Temperature Thermography
• Source:
  Opt Lett. 2013; 38(24):5228-5231
• Pubmed ID:
  24322224
• Pubmed Central ID:
  PMC3901074
• Document Type:
  Journal Article
• Funding:
  T32 EB014855/EB/NIBIB NIH HHSUnited States/ ; R01 CA134539/CA/NCI NIH HHSUnited States/ ; R01 CA157277/CA/NCI NIH HHSUnited States/ ; U54 CA136398/CA/NCI NIH HHSUnited States/ ; R01 CA159959/CA/NCI NIH HHSUnited States/ ; DP1 EB016986/EB/NIBIB NIH HHSUnited States/ ; R01 EB008085/EB/NIBIB NIH HHSUnited States/ ; DP1 EB016986/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  38
• Issue:
  24
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cf6e3e49538e3a08b44f4fef8d9974c2e4f1c7ccd1f2d885e3c7ac03251f424e
• Download URL:
  https://stacks.cdc.gov/view/cdc/29836/cdc_29836_DS1.pdf
• File Type:
  [PDF - 663.92 KB ]