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Molecular modeling in structural nano-toxicology: Interactions of nano-particles with nano-machinery of cells
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12 2013
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Source: Adv Drug Deliv Rev. 65(15):2070-2077
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Alternative Title:Adv Drug Deliv Rev
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Description:Over the past two decades, nanotechnology has emerged as a key player in various disciplines of science and technology. Some of the most exciting applications are in the field of biomedicine - for theranostics (for combined diagnostic and therapeutic purposes) as well as for exploration of biological systems. A detailed understanding of the molecular interactions between nanoparticles and biological nano-machinery - macromolecules, membranes, and intracellular organelles - is crucial for obtaining adequate information on mechanisms of action of nanomaterials as well as a perspective on the long term effects of these materials and their possible toxicological outcomes. This review focuses on the use of structure-based computational molecular modeling as a tool to understand and to predict the interactions between nanomaterials and nano-biosystems. We review major approaches and provide examples of computational analysis of the structural principles behind such interactions. A rationale on how nanoparticles of different sizes, shape, structure and chemical properties can affect the organization and functions of nano-machinery of cells is also presented.
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Pubmed ID:23726945
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Pubmed Central ID:PMC3819408
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Volume:65
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Issue:15
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