Angiotensin Receptor Blockers and Risk of Prostate Cancer among United States Veterans

Details

• Alternative Title:
  J Clin Pharmacol
• Personal Author:
  Rao, Gowtham A ; Mann, Joshua R. ; Bottai, Matteo ; Uemura, Hiroji ; Burch, James B ; Bennett, Charles Lee ; Haddock, Kathlyn Sue ; Hébert, James R
• Description:
  Objectives
  
  To address concerns regarding increased risk of prostate cancer (PrCA) among Angiotensin Receptor Blocker users, we used national retrospective data from the Department of Veterans Affairs (VA) through the Veterans Affairs Informatics and Computing Infrastructure (VINCI).
  
  Methods
  
  We identified a total of 543,824 unique Veterans who were classified into either ARB treated or not-treated in 1:15 ratio. The two groups were balanced using inverse probability of treatment weights. A double-robust cox-proportional hazards model was used to estimate the hazard ratio for PrCA incidence. To evaluate for a potential Gleason score stage migration we conducted weighted Cochrane-Armitage test.
  
  Results
  
  Post weighting, the rates of PrCA in treated and not-treated groups were 506 (1.5%) and 8,269 (1.6%), respectively; representing a hazard ratio of (0.91, p-value 0.049). There was no significant difference in Gleason scores between the two groups.
  
  Conclusions
  
  We found a small, but statistically significant, reduction in the incidence of clinically detected PrCA among patients assigned to receive ARB with no countervailing effect on degree of differentiation (as indicated by Gleason score). Findings from this study support FDA’s recent conclusion that ARB use does not increase risk of incident PrCA.
  
  
• Subjects:
  Aged Angiotensin Receptor Antagonists Cohort Studies Humans Male Middle Aged Prostatic Neoplasms Retrospective Studies Risk Veterans
• Source:
  J Clin Pharmacol. 53(7):773-778.
• Pubmed ID:
  23686462
• Pubmed Central ID:
  PMC3768141
• Document Type:
  Journal Article
• Funding:
  K05 CA136975/CA/NCI NIH HHS/United States ; U48 DP001936,/DP/NCCDPHP CDC HHS/United States ; U54 CA153461/CA/NCI NIH HHS/United States ; U54CA153461/CA/NCI NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  53
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a26da7cfc229ea31a1f8393322d17dfeafba43a437bbd15a3ea5c16f62e56e40
• Download URL:
  https://stacks.cdc.gov/view/cdc/29729/cdc_29729_DS1.pdf
• File Type:
  [PDF - 298.48 KB ]