Details:

Alternative Title:
APMIS
Publisher's site:
http://dx.doi.org/10.1111/apm.12078
Personal Author:
Mbulaiteye, Sam M. ; Pullarkat, Sheeja T. ; Nathwani, Bharat N. ; Weiss, Lawrence M. ; Rao, Nagesh ; ... More +
Mbulaiteye, Sam M. ; Pullarkat, Sheeja T. ; Nathwani, Bharat N. ; Weiss, Lawrence M. ; Rao, Nagesh ; Emmanuel, Benjamin ; Lynch, Charles F. ; Hernandez, Brenda ; Neppalli, Vishala ; Hawes, Debra ; Cockburn, Myles G. ; Kim, Andre ; Williams, Makeda ; Altekruse, Sean ; Bhatia, Kishor ; Goodman, Marc T. ; Cozen, Wendy Less -
Description:
Background

Burkitt lymphoma (BL) occurs at all ages, but the patterns of Epstein-Barr virus (EBV) positivity in relation to human immunodeficiency virus (HIV), immunoprofiles and age have not been fully explored.

Design and methods

BL tissues from residual tissue repositories, and 2 academic centers in the United States were examined by expert hematopathologists for morphology, immunohistochemistry, MYC rearrangement, EBV early RNA (EBER), and diagnosed according to the 2008 WHO lymphoma classification. Analysis was done using frequency tables, Chi-squared statistics, and Student’s t-test.

Results

Of 117 cases examined, 91 were confirmed as BL. The age distribution was 26%, 15%, 19%, and 29% for 0-19, 20-34, 35-59, 60+ years, and missing in 11%. MYC rearrangement was found in 89% and EBER positivity in 29% of 82 cases with results. EBER positivity varied with age (from 13% in age-group 0-19 to 55% in age-group 20-34, and fell to 25% in age-group 60+ years, P=0.08); with race (56% in Blacks/Hispanics versus 21% in Whites/Asians/Pacific Islanders, P=0.006); and by HIV status (64% in HIV positive versus 22% in HIV negative cases, P=0.03).

Conclusions

EBER positivity was demonstrated in about one-third of tumors and it was strongly associated with race and HIV status, and marginally with age-group.


Subject:
[+]
Adolescent
Adult
Aged
Burkitt Lymphoma
Child
Child, Preschool
Female
Genes, Bcl-2
Genes, Myc
Herpesvirus 4, Human
Humans
Incidence
Infant
Infant, Newborn
Lymphoma, AIDS-Related
Male
Middle Aged
RNA, Viral
Time Factors
Young Adult

Source:
APMIS. 122(1):5-15.
Document Type:
Journal Article
Funding:
1U58DP000807-3/DP/NCCDPHP CDC HHS/United States ; HHSN261200900444P/PHS HHS/United States ; HHSN261200900586P/PHS HHS/United States ; N01-PC-2010-00035/PC/NCI NIH HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; ... More +
1U58DP000807-3/DP/NCCDPHP CDC HHS/United States ; HHSN261200900444P/PHS HHS/United States ; HHSN261200900586P/PHS HHS/United States ; N01-PC-2010-00035/PC/NCI NIH HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; N01-PC-35139/PC/NCI NIH HHS/United States ; N01-PC-35143/PC/NCI NIH HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; ZIA CP010150-010/Intramural NIH HHS/United States Less -
Name as Subject:
SEER Program
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0343aa28282bae06119361cdd2422d7e81f14e107b89fd14bf1e74617c587628
File Type:

Supporting Files

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