Epstein-Barr virus patterns in U.S. Burkitt lymphoma tumors from the SEER Residual Tissue Repository during 1979-2009

Details

• Alternative Title:
  APMIS
• Personal Author:
  Mbulaiteye, Sam M. ; Pullarkat, Sheeja T. ; Nathwani, Bharat N. ; Weiss, Lawrence M. ; Rao, Nagesh ; Emmanuel, Benjamin ; Lynch, Charles F. ; Hernandez, Brenda ; Neppalli, Vishala ; Hawes, Debra ; Cockburn, Myles G. ; Kim, Andre ; Williams, Makeda ; Altekruse, Sean ; Bhatia, Kishor ; Goodman, Marc T. ; Cozen, Wendy
• Description:
  Background
  
  Burkitt lymphoma (BL) occurs at all ages, but the patterns of Epstein-Barr virus (EBV) positivity in relation to human immunodeficiency virus (HIV), immunoprofiles and age have not been fully explored.
  
  Design and methods
  
  BL tissues from residual tissue repositories, and 2 academic centers in the United States were examined by expert hematopathologists for morphology, immunohistochemistry, MYC rearrangement, EBV early RNA (EBER), and diagnosed according to the 2008 WHO lymphoma classification. Analysis was done using frequency tables, Chi-squared statistics, and Student’s t-test.
  
  Results
  
  Of 117 cases examined, 91 were confirmed as BL. The age distribution was 26%, 15%, 19%, and 29% for 0-19, 20-34, 35-59, 60+ years, and missing in 11%. MYC rearrangement was found in 89% and EBER positivity in 29% of 82 cases with results. EBER positivity varied with age (from 13% in age-group 0-19 to 55% in age-group 20-34, and fell to 25% in age-group 60+ years, P=0.08); with race (56% in Blacks/Hispanics versus 21% in Whites/Asians/Pacific Islanders, P=0.006); and by HIV status (64% in HIV positive versus 22% in HIV negative cases, P=0.03).
  
  Conclusions
  
  EBER positivity was demonstrated in about one-third of tumors and it was strongly associated with race and HIV status, and marginally with age-group.
  
  
• Subjects:
  Adolescent Adult Aged Burkitt Lymphoma Child Child, Preschool Female Genes, Bcl-2 Genes, Myc Herpesvirus 4, Human Humans Incidence Infant Infant, Newborn Lymphoma, AIDS-Related Male Middle Aged RNA, Viral Time Factors Young Adult

  More +
• Source:
  APMIS. 122(1):5-15.
• Document Type:
  Journal Article
• Funding:
  1U58DP000807-3/DP/NCCDPHP CDC HHS/United States ; HHSN261200900444P/PHS HHS/United States ; HHSN261200900586P/PHS HHS/United States ; N01-PC-2010-00035/PC/NCI NIH HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; N01-PC-35139/PC/NCI NIH HHS/United States ; N01-PC-35143/PC/NCI NIH HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; ZIA CP010150-010/Intramural NIH HHS/United States
• Name as Subject:
  SEER Program
• Place as Subject:
  United States
• Volume:
  122
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0343aa28282bae06119361cdd2422d7e81f14e107b89fd14bf1e74617c587628
• Download URL:
  https://stacks.cdc.gov/view/cdc/29693/cdc_29693_DS1.pdf
• File Type:
  [PDF - 677.18 KB ]