Functional inhibition of UQCRB suppresses angiogenesis in zebrafish
Published Date:Feb 28 2013
Source:Biochem Biophys Res Commun. 2013; 433(4):396-400.
Keywords:Amino Acid Sequence
Dose-Response Relationship, Drug
Gene Expression Regulation, Developmental
Gene Knockdown Techniques
Molecular Sequence Data
Vascular Endothelial Growth Factor A
Pubmed Central ID:PMC3691074
Funding:DP1 HD075622/HD/NICHD NIH HHS/United States
DP1HD075622/DP/NCCDPHP CDC HHS/United States
Description:As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.
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