Details:

Alternative Title:
Paediatr Perinat Epidemiol
Publisher's site:
http://dx.doi.org/10.1111/ppe.12064
Personal Author:
Ahrens, Katherine A. ; Anderka, Marlene T. ; Feldkamp, Marcia L. ; Canfield, Mark A. ; Mitchell, Allen A. ; ... More +
Ahrens, Katherine A. ; Anderka, Marlene T. ; Feldkamp, Marcia L. ; Canfield, Mark A. ; Mitchell, Allen A. ; Werler, Martha M. Less -
Description:
Background

Previous studies examining the teratogenic effects of antiherpetic medications have found no associations for birth defects overall but have not examined the risk of specific birth defects.

Methods

The National Birth Defects Prevention Study ascertains population-based cases with birth defects and live-born controls without birth defects in ten states across the United States for the purpose of identifying potential teratogenic risk factors. Mothers of cases and controls are interviewed within two years of their estimated date of delivery about demographic, medical and behavioral factors before and during pregnancy. This analysis examined the possible association between use of antiherpetic medications (acyclovir, valacyclovir or famciclovir) during early pregnancy and gastroschisis, a birth defect of the abdominal wall.

Results

The mothers of 1.1% (n=10) of 941 gastroschisis cases and 0.3% (n=27) of 8339 controls reported antiherpetic medication use during the month before conception through the third month of pregnancy. The adjusted odds ratios for such use in relation to gastroschisis were 4.68 (95% confidence interval [1.65, 13.28]) and 4.68 [1.15, 19.03] among women with and without self-reported genital herpes, respectively, when compared to women without antiherpetic use or herpes. Among women reporting no antiherpetic medication use, the odds ratio for self-reported genital herpes in relation to gastroschisis was 3.00 [1.58, 5.68].

Conclusions

Our study raises the possibility of an increased risk of gastroschisis due to either antiherpetic medication use during early pregnancy or the underlying genital herpes infection for which it was indicated.


Subject:
[+]
2-Aminopurine
Acyclovir
Adolescent
Adult
Antiviral Agents
Case-Control Studies
Female
Gastroschisis
Herpes Simplex
Humans
Infant, Newborn
Maternal Exposure
Middle Aged
Pregnancy
Regression Analysis
Valine
Young Adult

Source:
Paediatr Perinat Epidemiol. 27(4):340-345.
Document Type:
Journal Article
Funding:
FOA DD09-001/DD/NCBDD CDC HHS/United States ; PA 02081/PHS HHS/United States ; PA 96043/PHS HHS/United States ; T32 HD052458/HD/NICHD NIH HHS/United States
FOA DD09-001/DD/NCBDD CDC HHS/United States ; PA 02081/PHS HHS/United States ; PA 96043/PHS HHS/United States ; T32 HD052458/HD/NICHD NIH HHS/United States Less -
Name as Subject:
National Birth Defects Prevention Study (U.S.)
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8729a5da782b652c8f6ceab8cc96313673271545c9c8dcaa74d3e94e9a28e05e
File Type:

Supporting Files

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  	nihms-479044-f0001.jpg	jpeg
  	nihms-479044.nxml	txt

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