Anthropometric, behavioral, and female reproductive factors and risk of multiple myeloma: a pooled analysis

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Wang, Sophia S. ; Voutsinas, Jenna ; Chang, Ellen T. ; Clarke, Christina A. ; Lu, Yani ; Ma, Huiyan ; West, Dee ; Lacey, James V. ; Bernstein, Leslie
• Description:
  Background
  
  Risk of developing multiple myeloma (MM) rises with age and is greater among men and blacks than among women and whites, respectively, and possibly increased among obese persons. Other risk factors remain poorly understood. By pooling data from two complementary epidemiologic studies, we assessed whether obesity, smoking, or alcohol consumption alters MM risk and whether female reproductive history might explain the lower occurrence of MM in females than males.
  
  Methods
  
  The Los Angeles County MM Case-Control Study (1985-92) included 278 incident cases and 278 controls, matched on age, sex, race, and neighborhood of residence at case’s diagnosis. We estimated MM risk using conditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI). In the prospective California Teachers Study (CTS), 152 women were diagnosed with incident MM between 1995-2009; we calculated hazard ratios using Cox proportional hazards analysis. Data from the two studies were pooled using a stratified, nested case-control sampling scheme (10:1 match) for the CTS; conditional logistic regression among 430 cases and 1,798 matched controls was conducted.
  
  Results
  
  Obesity and smoking were not associated with MM risk in the individual or combined studies. Alcohol consumption was associated with decreased MM risk among whites only (pooled OR=0.66, 95% CI=0.49-0.90) for ever vs. never drinking). Higher gravidity and parity were associated with increased MM risk, with pooled ORs of 1.38 (95% CI=1.01-1.90) for ≥3 versus 1-2 pregnancies and 1.50 (95% CI=1.09-2.06) for ≥3 versus 1-2 live births.
  
  Conclusions
  
  Female reproductive history may modestly alter MM risk, but appears unlikely to explain the sex disparity in incidence. Further investigation in consortial efforts is warranted.
  
  
• Subjects:
  Adult Aged Alcohol Drinking Anthropometry Article Association Case-control Case-Control Studies Cohort Cohort Studies Epidemiology Female Humans Logistic Models Los Angeles Male Middle Aged Modifiable Multiple Myeloma Obesity Odds Ratio Pooling Reproductive Reproductive History Risk Assessment Risk Factors Sex Factors Women

  More +
• Source:
  Cancer Causes Control. 24(7):1279-1289.
• Pubmed ID:
  23568533
• Pubmed Central ID:
  PMC3684420
• Document Type:
  Journal Article
• Funding:
  HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000140C/PHS HHS/United States ; K05CA136967/CA/NCI NIH HHS/United States ; R01 CA077398/CA/NCI NIH HHS/United States ; R01CA036388/CA/NCI NIH HHS/United States ; R01CA077398/CA/NCI NIH HHS/United States ; U58DP003862-01/DP/NCCDPHP CDC HHS/United States
• Volume:
  24
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0255879f54ca1cc0e45488749c5f375ba7038f6e3cca5d5f7f600a2547ac846b
• Download URL:
  https://stacks.cdc.gov/view/cdc/29675/cdc_29675_DS1.pdf
• File Type:
  [PDF - 525.62 KB ]