Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi
Published Date:Jan 31 2013
Source:Org Lett. 15(4):780-783.
Funding:1DP1GM106413/DP/NCCDPHP CDC HHS/United States
1R01GM085128/GM/NIGMS NIH HHS/United States
DP1 GM106413/GM/NIGMS NIH HHS/United States
R01 AI073829/AI/NIAID NIH HHS/United States
R01 GM085128/GM/NIGMS NIH HHS/United States
R01AI073829/AI/NIAID NIH HHS/United States
UL1 TR000124/TR/NCATS NIH HHS/United States
Description:Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC(50) of 3 μM, suggestive of a physiological role as an immunosuppressive agent.
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