Severe Morbidity and Mortality Risk From Malaria in the United States, 1985–2011

Details

• Alternative Title:
  Open Forum Infect Dis
• Personal Author:
  Hwang, Jimee ; Cullen, Karen A. ; Kachur, S. Patrick ; Arguin, Paul M. ; Baird, J. Kevin
• Description:
  Background.
  
   Recent reports of Plasmodium vivax associated with severe syndromes and mortality from malaria endemic areas questions the “benign” course of non-falciparum malarias.
  
  Methods.
  
   We retrospectively analyzed data from patients reported to the US Centers for Disease Control and Prevention with a diagnosis of malaria parasite single-species infection between 1985 and 2011. Patients classified as having severe illness were further classified according to outcome (survival versus death) and clinical syndrome.
  
  Results.
  
   Among all cases, .9% of Plasmodium falciparum cases resulted in death and 9.3% were classified as severe, whereas .09% of P. vivax cases resulted in death and 1.3% were classified as severe. The odds ratios for severe illness among 15 272 diagnoses of P. falciparum relative to patients diagnosed with P. vivax (n = 12 152), Plasmodium malariae (n = 1254), or Plasmodium ovale (n = 903) was 7.5, 5.7, and 5.0, respectively (P < .0001 for all); in contrast, the corresponding odds ratios for death among those severely ill was 1.6, 1.1, and .8 (P > .1 for all), respectively. Compared with P. vivax (n = 163), the odds of P. falciparum cases classified as severely ill (n = 1416) were 1.9 (P = .0006), .5 (P = .001), and 1.3 times (P = .1) as likely to present as cerebral, acute respiratory distress, and renal syndromes, respectively.
  
  Conclusions.
  
   Although less common, patients presenting with non-falciparum even in the United States can develop severe illness, and severe illness in patients having malaria of any species threatens life.
  
  
• Subjects:
  Malaria Risk
• Source:
  Open Forum Infect Dis. 2014; 1(1).
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  1
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:6ef360d2feed0e182f26c72c6b647e41970189e422d0d4b0c2f3abcb39077f32
• Download URL:
  https://stacks.cdc.gov/view/cdc/28182/cdc_28182_DS1.pdf
• File Type:
  [PDF - 669.38 KB ]