Model Selection Emphasises the Importance of Non-Chromosomal Information in Genetic Studies

Rawi, Reda; El Anbari, Mohamed; Bensmail, Halima

doi:10.1371/journal.pone.0117014

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Model Selection Emphasises the Importance of Non-Chromosomal Information in Genetic Studies

Jan 27 2015
By Rawi, Reda ; El Anbari, Mohamed ; Bensmail, Halima
http://dx.doi.org/10.1371/journal.pone.0117014
Source: PLoS One. 2015; 10(1).

[PDF-648.85 KB]

English

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PLoS One
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Rawi, Reda ; El Anbari, Mohamed ; Bensmail, Halima

Rawi, Reda ; El Anbari, Mohamed ; Bensmail, Halima Less -
Description:

Ever since the case of the missing heritability was highlighted some years ago, scientists have been investigating various possible explanations for the issue. However, none of these explanations include non-chromosomal genetic information. Here we describe explicitly how chromosomal and non-chromosomal modifiers collectively influence the heritability of a trait, in this case, the growth rate of yeast. Our results show that the non-chromosomal contribution can be large, adding another dimension to the estimation of heritability. We also discovered, combining the strength of LASSO with model selection, that the interaction of chromosomal and non-chromosomal information is essential in describing phenotypes.
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Bayes Theorem Chromosomes, Fungal Genetic Association Studies Linear Models Models, Genetic Mutation Saccharomyces Cerevisiae
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PLoS One. 2015; 10(1).
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Journal Article
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CDC Public Access
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urn:sha256:9c0963c8f4b5904b237eaa2d5fc7464bd00d46b26d47d04b472e176ca9d59604
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https://stacks.cdc.gov/view/cdc/28059/cdc_28059_DS1.pdf
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