Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0083075
Personal Author:
Rey, Gertrud U. ; Miao, Congrong ; Caidi, Hayat ; Trivedi, Suvang U. ; Harcourt, Jennifer L. ; ... More +
Rey, Gertrud U. ; Miao, Congrong ; Caidi, Hayat ; Trivedi, Suvang U. ; Harcourt, Jennifer L. ; Tripp, Ralph A. ; Anderson, Larry J. ; Haynes, Lia M. Less -
Description:
Respiratory syncytial virus (RSV) is a high priority target for vaccine development. One concern in RSV vaccine development is that a non-live virus vaccine would predispose for enhanced disease similar to that seen with the formalin inactivated RSV (FI-RSV) vaccine. Since a mAb specific to RSV G protein can reduce pulmonary inflammation and eosinophilia seen after RSV infection of FI-RSV vaccinated mice, we hypothesized that RSV G peptides that induce antibodies with similar reactivity may limit enhanced disease after subunit or other non-live RSV vaccines. In support of this hypothesis, we show that FI-RSV vaccinated mice administered RSV G peptide vaccines had a significant reduction in enhanced disease after RSV challenge. These data support the importance of RSV G during infection to RSV disease pathogenesis and suggest that use of appropriately designed G peptide vaccines to reduce the risk of enhanced disease with non-live RSV vaccines merits further study.
Subject:
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Amino Acid Sequence
Animals
Antibodies, Viral
Formaldehyde
Immunization
Lung
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Peptides
Research Article
Respiratory Syncytial Viruses
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Vaccines
Vaccines, Inactivated
Viral Fusion Proteins

Source:
PLoS One. 2013; 8(12).
Document Type:
Journal Article
Funding:
5R01AI06275-03/AI/NIAID NIH HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2e87e5b26e6a4836bde3f3565faa5b0d811fc6443239ea89d3eb928bbb25ad0f
File Type:

Supporting Files

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