Decrease in Formalin-Inactivated Respiratory Syncytial Virus (FI-RSV) Enhanced Disease with RSV G Glycoprotein Peptide Immunization in BALB/c Mice

Rey, Gertrud U.; Miao, Congrong; Caidi, Hayat; Trivedi, Suvang U.; Harcourt, Jennifer L.; Tripp, Ralph A.; Anderson, Larry J.; Haynes, Lia M.

doi:10.1371/journal.pone.0083075

i

Decrease in Formalin-Inactivated Respiratory Syncytial Virus (FI-RSV) Enhanced Disease with RSV G Glycoprotein Peptide Immunization in BALB/c Mice

Supporting Files

Dec 23 2013
By Rey, Gertrud U. ; Miao, Congrong ; Caidi, Hayat ; ...

File Language:

English

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Alternative Title:

PLoS One
Personal Author:

Rey, Gertrud U. ; Miao, Congrong ; Caidi, Hayat ; Trivedi, Suvang U. ; Harcourt, Jennifer L. ; Tripp, Ralph A. ; Anderson, Larry J. ; Haynes, Lia M.
Description:

Respiratory syncytial virus (RSV) is a high priority target for vaccine development. One concern in RSV vaccine development is that a non-live virus vaccine would predispose for enhanced disease similar to that seen with the formalin inactivated RSV (FI-RSV) vaccine. Since a mAb specific to RSV G protein can reduce pulmonary inflammation and eosinophilia seen after RSV infection of FI-RSV vaccinated mice, we hypothesized that RSV G peptides that induce antibodies with similar reactivity may limit enhanced disease after subunit or other non-live RSV vaccines. In support of this hypothesis, we show that FI-RSV vaccinated mice administered RSV G peptide vaccines had a significant reduction in enhanced disease after RSV challenge. These data support the importance of RSV G during infection to RSV disease pathogenesis and suggest that use of appropriately designed G peptide vaccines to reduce the risk of enhanced disease with non-live RSV vaccines merits further study.
Subjects:

Amino Acid Sequence Animals Antibodies, Viral Formaldehyde Immunization Lung Mice Mice, Inbred BALB C Molecular Sequence Data Peptides Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Respiratory Syncytial Virus Vaccines Vaccines, Inactivated Viral Fusion Proteins
Source:

PLoS One. 2013; 8(12).
Document Type:

Journal Article
Funding:

5R01AI06275-03/AI/NIAID NIH HHS/United States
Volume:

8
Issue:

12
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:2e87e5b26e6a4836bde3f3565faa5b0d811fc6443239ea89d3eb928bbb25ad0f
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https://stacks.cdc.gov/view/cdc/28012/cdc_28012_DS1.pdf
File Type:

[PDF - 2.05 MB ]

File Language:

English

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