Chronic, Wireless Recordings of Large Scale Brain Activity in Freely Moving Rhesus Monkeys

Details

• Alternative Title:
  Nat Methods
• Personal Author:
  Schwarz, David A. ; Lebedev, Mikhail A. ; Hanson, Timothy L. ; Dimitrov, Dragan F. ; Lehew, Gary ; Meloy, Jim ; Rajangam, Sankaranarayani ; Subramanian, Vivek ; Ifft, Peter J. ; Li, Zheng ; Ramakrishnan, Arjun ; Tate, Andrew ; Zhuang, Katie ; Nicolelis, Miguel A.L.
• Description:
  Advances in techniques for recording large-scale brain activity contribute to both the elucidation of neurophysiological principles and the development of brain-machine interfaces (BMIs). Here we describe a neurophysiological paradigm for performing tethered and wireless large-scale recordings based on movable volumetric three-dimensional (3D) multielectrode implants. This approach allowed us to isolate up to 1,800 neurons (units) per animal and simultaneously record the extracellular activity of close to 500 cortical neurons, distributed across multiple cortical areas, in freely behaving rhesus monkeys. The method is expandable, in principle, to thousands of simultaneously recorded channels. It also allows increased recording longevity (5 consecutive years) and recording of a broad range of behaviors, such as social interactions, and BMI paradigms in freely moving primates. We propose that wireless large-scale recordings could have a profound impact on basic primate neurophysiology research while providing a framework for the development and testing of clinically relevant neuroprostheses.
• Keywords:
  Animals Brain Electrodes, Implanted Electronic Data Processing Macaca Mulatta Neurophysiology Wireless Technology
• Source:
  Nat Methods. 11(6):670-676
• Pubmed ID:
  24776634
• Pubmed Central ID:
  PMC4161037
• Document Type:
  Journal Article
• Funding:
  T32 GM008441/GM/NIGMS NIH HHSUnited States/ ; DP1 MH099903/MH/NIMH NIH HHSUnited States/ ; UL1 TR001117/TR/NCATS NIH HHSUnited States/ ; R01 NS073952/NS/NINDS NIH HHSUnited States/ ; DP1 OD006798/OD/NIH HHSUnited States/ ; DP1MH099903/DP/NCCDPHP CDC HHSUnited States/ ; R01NS073952/NS/NINDS NIH HHSUnited States/
• Volume:
  11
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e4dc3905f76fe51ca1c0f1cdfa4b0059bf8a4d66d95ec0ae32ae14366a5fc14d
• Download URL:
  https://stacks.cdc.gov/view/cdc/27885/cdc_27885_DS1.pdf
• File Type:
  [PDF - 3.83 MB ]