HIV/AIDS-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites

Details

• Alternative Title:
  Glob Health Action
• Personal Author:
  Streatfield, P. Kim ; Khan, Wasif A. ; Bhuiya, Abbas ; Hanifi, Syed M.A. ; Alam, Nurul ; Millogo, Ourohiré ; Sié, Ali ; Zabré, Pascal ; Rossier, Clementine ; Soura, Abdramane B. ; Bonfoh, Bassirou ; Kone, Siaka ; Ngoran, Eliezer K. ; Utzinger, Juerg ; Abera, Semaw F. ; Melaku, Yohannes A. ; Weldearegawi, Berhe ; Gomez, Pierre ; Jasseh, Momodou ; Ansah, Patrick ; Azongo, Daniel ; Kondayire, Felix ; Oduro, Abraham ; Amu, Alberta ; Gyapong, Margaret ; Kwarteng, Odette ; Kant, Shashi ; Pandav, Chandrakant S. ; Rai, Sanjay K. ; Juvekar, Sanjay ; Muralidharan, Veena ; Wahab, Abdul ; Wilopo, Siswanto ; Bauni, Evasius ; Mochamah, George ; Ndila, Carolyne ; Williams, Thomas N. ; Khagayi, Sammy ; Laserson, Kayla F. ; Nyaguara, Amek ; Van Eijk, Anna M. ; Ezeh, Alex ; Kyobutungi, Catherine ; Wamukoya, Marylene ; Chihana, Menard ; Crampin, Amelia ; Price, Alison ; Delaunay, Valérie ; Diallo, Aldiouma ; Douillot, Laetitia ; Sokhna, Cheikh ; Gómez-Olivé, F. Xavier ; Mee, Paul ; Tollman, Stephen M. ; Herbst, Kobus ; Mossong, Joël ; Chuc, Nguyen T.K. ; Arthur, Samuelina S. ; Sankoh, Osman A. ; Byass, Peter
• Description:
  Background
  
  As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the individual level. Systematic application of verbal autopsy (VA) methods in defined populations provides an opportunity to assess the mortality burden of the pandemic from individual data.
  
  Objective
  
  To present standardised comparisons of HIV/AIDS-related mortality at sites across Africa and Asia, including closely related causes of death such as pulmonary tuberculosis (PTB) and pneumonia.
  
  Design
  
  Deaths related to HIV/AIDS were extracted from individual demographic and VA data from 22 INDEPTH sites across Africa and Asia. VA data were standardised to WHO 2012 standard causes of death assigned using the InterVA-4 model. Between-site comparisons of mortality rates were standardised using the INDEPTH 2013 standard population.
  
  Results
  
  The dataset covered a total of 10,773 deaths attributed to HIV/AIDS, observed over 12,204,043 person-years. HIV/AIDS-related mortality fractions and mortality rates varied widely across Africa and Asia, with highest burdens in eastern and southern Africa, and lowest burdens in Asia. There was evidence of rapidly declining rates at the sites with the heaviest burdens. HIV/AIDS mortality was also strongly related to PTB mortality. On a country basis, there were strong similarities between HIV/AIDS mortality rates at INDEPTH sites and those derived from modelled estimates.
  
  Conclusions
  
  Measuring HIV/AIDS-related mortality continues to be a challenging issue, all the more so as anti-retroviral treatment programmes alleviate mortality risks. The congruence between these results and other estimates adds plausibility to both approaches. These data, covering some of the highest mortality observed during the pandemic, will be an important baseline for understanding the future decline of HIV/AIDS.
  
  
• Subjects:
  Acquired Immunodeficiency Syndrome Adolescent Adult Aged Autopsy Cause Of Death Child Child, Preschool Databases, Factual Data Collection Demography Female HIV Infections Humans Infant Infant, Newborn Male Middle Aged Population Surveillance

  More +
• Source:
  Glob Health Action. 2014; 7.
• Pubmed ID:
  25377330
• Pubmed Central ID:
  PMC4220131
• Document Type:
  Journal Article
• Funding:
  058893/Z/99/A/Wellcome Trust/United Kingdom ; 069683/Z/02/Z/Wellcome Trust/United Kingdom ; 084538/Wellcome Trust/United Kingdom ; 085477/Z/08/Z/Wellcome Trust/United Kingdom ; 091758/Wellcome Trust/United Kingdom ; 5U22/PS022179_10/PS/NCHHSTP CDC HHS/United States ; MC_UP_A900_1123/Medical Research Council/United Kingdom ; WT081993MA/Wellcome Trust/United Kingdom ; Medical Research Council/United Kingdom
• Name as Subject:
  INDEPTH Network ; INDEPTH Network
• Place as Subject:
  Africa ; Asia
• Volume:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:54f2003dfab0292d254f5928f07ccaa952612be233b6a73b9245989423e9685e
• Download URL:
  https://stacks.cdc.gov/view/cdc/27876/cdc_27876_DS1.pdf
• File Type:
  [PDF - 703.71 KB ]