Peripheral Neuropathy in Adolescents and Young Adults With Type 1 and Type 2 Diabetes From the SEARCH for Diabetes in Youth Follow-up Cohort

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Jaiswal, Mamta ; Lauer, Abigail ; Martin, Catherine L. ; Bell, Ronny A. ; Divers, Jasmin ; Dabelea, Dana ; Pettitt, David J. ; Saydah, Sharon ; Pihoker, Catherine ; Standiford, Debra A. ; Rodriguez, Beatriz L. ; Pop-Busui, Rodica ; Feldman, Eva L.
• Corporate Authors:
  for the SEARCH for Diabetes in Youth Study Group
• Description:
  OBJECTIVE
  
  To estimate the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in a pilot study among youth participating in the SEARCH for Diabetes in Youth study.
  
  RESEARCH DESIGN AND METHODS
  
  DPN was assessed using the Michigan Neuropathy Screening Instrument (MNSI) (examination for foot abnormalities, distal vibration perception, and ankle reflexes). An MNSI exam (MNSIE) score >2 is diagnostic for DPN.
  
  RESULTS
  
  The MNSIE was completed in 399 subjects, including 329 youth with type 1 diabetes (mean age 15.7 ± 4.3 years, duration 6.2 ± 0.9 years) and 70 with type 2 diabetes (mean age 21.6 ± 4.1 years, duration 7.6 ± 1.8 years). Glycated hemoglobin (A1C) was similar in both groups (8.8 ± 1.8% for type 1 vs. 8.5 ± 2.9% for type 2). The prevalence of DPN was significantly higher in youth with type 2 compared with those with type 1 diabetes (25.7 vs. 8.2%; P < 0.0001). In unadjusted analyses, diabetes type, older age, longer duration of diabetes, increased waist circumference, elevated blood pressure, lower HDL cholesterol, and presence of microalbuminuria (urinary albumin-to-creatinine ratio >30 mg/g) were associated with DPN. The association between diabetes type and DPN remained significant after adjustment for age and sex (odds ratio 2.29 [95% CI 1.05–5.02], P = 0.03).
  
  CONCLUSIONS
  
  DPN prevalence among youth with type 2 diabetes approached rates reported in adult populations with diabetes. Our findings suggest not only that youth with diabetes are at risk for DPN but also that many already show measurable signs of DPN.
  
  
• Subjects:
  Adolescent Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetic Neuropathies Female Follow-Up Studies Hemoglobin A, Glycosylated Humans Male Pilot Projects Population Surveillance Prevalence Risk Factors Young Adult

  More +
• Source:
  Diabetes Care. 2013; 36(12):3903-3908.
• Pubmed ID:
  24144652
• Pubmed Central ID:
  PMC3836139
• Document Type:
  Journal Article
• Funding:
  1U18DP002709/DP/NCCDPHP CDC HHS/United States ; 1UL1RR026314-01/RR/NCRR NIH HHS/United States ; 200-2010-35171/PHS HHS/United States ; DP-05-069/DP/NCCDPHP CDC HHS/United States ; DP-10-001/DP/NCCDPHP CDC HHS/United States ; M01 RR00069/RR/NCRR NIH HHS/United States ; M01RR00037/RR/NCRR NIH HHS/United States ; P30 DK57516/DK/NIDDK NIH HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; U01 DP000245/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States ; U18DP002708-01/DP/NCCDPHP CDC HHS/United States ; U18DP002710-01/DP/NCCDPHP CDC HHS/United States ; U18DP002714/DP/NCCDPHP CDC HHS/United States ; U48/CCU419249/PHS HHS/United States ; U48/CCU519239/PHS HHS/United States ; U48/CCU819241-3/PHS HHS/United States ; U48/CCU919219/PHS HHS/United States ; U58/CCU019235-4/PHS HHS/United States ; U58CCU919256/PHS HHS/United States ; UL1 RR029882/RR/NCRR NIH HHS/United States ; UL1 TR000077/TR/NCATS NIH HHS/United States ; UL1RR029882/RR/NCRR NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  36
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ab02c0385d549112fe27a981d8cd417b8727026cf4df54e1fe7952629ef9bb17
• Download URL:
  https://stacks.cdc.gov/view/cdc/27865/cdc_27865_DS1.pdf
• File Type:
  [PDF - 112.74 KB ]