Details:

Alternative Title:
Front Oncol
Personal Author:
Hernandez, Brenda Y. ; Goodman, Marc T. ; Unger, Elizabeth R. ; Steinau, Martin ; Powers, Amy ; ... More +
Hernandez, Brenda Y. ; Goodman, Marc T. ; Unger, Elizabeth R. ; Steinau, Martin ; Powers, Amy ; Lynch, Charles F. ; Cozen, Wendy ; Saber, Maria Sibug ; Peters, Edward S. ; Wilkinson, Edward J. ; Copeland, Glenn ; Hopenhayn, Claudia ; Huang, Youjie ; Watson, Meg ; Altekruse, Sean F. ; Lyu, Christopher ; Saraiya, Mona Less -
Corporate Authors:
The HPV Typing of Cancer Workgroup
Description:
Human papillomavirus (HPV) is estimated to play an etiologic role in 40-50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited.|HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998-2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review.|HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status.|The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.
Subjects:
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HPV Human Papillomavirus Oncology Penile Cancer Prevalence
Source:
Front Oncol. 2014; 4.
Document Type:
Journal Article
Funding:
P30 CA071789/CA/NCI NIH HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States
P30 CA071789/CA/NCI NIH HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:542543099e94e0b304f4dcf75b1f1cc482bf2a2d412d814aeb3b6961f170b326
Download URL:
https://stacks.cdc.gov/view/cdc/27852/cdc_27852_DS1.pdf
File Type:

Supporting Files

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