Vascular events in viral hemorrhagic fevers: a comparative study of dengue and hantaviruses

Details

• Alternative Title:
  Cell Tissue Res
• Personal Author:
  Srikiatkhachorn, Anon ; Spiropoulou, Christina F.
• Description:
  Viral hemorrhagic diseases are a group of systemic viral infections with worldwide distribution and are significant causes of global mortality and morbidity. The hallmarks of viral hemorrhagic fevers are plasma leakage, thrombocytopenia, coagulopathy and hemorrhagic manifestations. The molecular mechanisms leading to plasma leakage in viral hemorrhagic fevers are not well understood. A common theme has emerged in which a complex interplay between pathogens, host immune response, and endothelial cells leads to the activation of endothelial cells and perturbation of barrier integrity. In this article, two clinically distinct viral hemorrhagic fevers caused by dengue viruses and hantaviruses are discussed to highlight their similarities and differences that may provide insights into the pathogenesis and therapeutic approach.
• Subjects:
  Animals Dengue Virus Dengue Viruses Endothelial Cells Endothelium Endothelium, Vascular Hantavirus Hantaviruses Hemorrhagic Fevers, Viral Humans Permeability Review Viral Hemorrhagic Fevers

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• Source:
  Cell Tissue Res. 355(3):621-633
• Pubmed ID:
  24623445
• Pubmed Central ID:
  PMC3972431
• Document Type:
  Journal Article
• Funding:
  P01 AI034533/AI/NIAID NIH HHS/United States ; P01AI34533/AI/NIAID NIH HHS/United States
• Volume:
  355
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cab7af23f2a00d7b409b0246f0ea197a99956916f33536615b7c851c083c4a88
• Download URL:
  https://stacks.cdc.gov/view/cdc/27656/cdc_27656_DS1.pdf
• File Type:
  [PDF - 637.96 KB ]