Comparison of Patients Hospitalized With Influenza A Subtypes H7N9, H5N1, and
2009 Pandemic H1N1

Wang, Chen; Yu, Hongjie; Horby, Peter W.; Cao, Bin; Wu, Peng; Yang, Shigui; Gao, Hainv; Li, Hui; Tsang, Tim K.; Liao, Qiaohong; Gao, Zhancheng; Ip, Dennis K. M.; Jia, Hongyu; Jiang, Hui; Liu, Bo; Ni, Michael Y.; Dai, Xiahong; Liu, Fengfeng; Van Kinh, Nguyen; Liem, Nguyen Thanh; Hien, Tran Tinh; Li, Yu; Yang, Juan; Wu, Joseph T.; Zheng, Yaming; Leung, Gabriel M.; Farrar, Jeremy J.; Cowling, Benjamin J.; Uyeki, Timothy M.; Li, Lanjuan

doi:10.1093/cid/ciu053

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Comparison of Patients Hospitalized With Influenza A Subtypes H7N9, H5N1, and 2009 Pandemic H1N1

Published Date:

Jan 31 2014

Publisher's site:

http://dx.doi.org/10.1093/cid/ciu053 New Site Icon

Source:

Clin Infect Dis. 2014; 58(8):1095-1103.

[PDF-405.46 KB]

Details:

Alternative Title:

Clin Infect Dis

Personal Author:

Wang, Chen ; Yu, Hongjie ; Horby, Peter W. ; Cao, Bin ; Wu, Peng ; ... More ▼

Description:

Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression of patients hospitalized with H7N9, H5N1, and 2009 pandemic H1N1 (pH1N1) virus infections.|We compared individual-level data from patients hospitalized with infection by H7N9 (n = 123), H5N1 (n = 119; 43 China, 76 Vietnam), and pH1N1 (n = 3486) viruses. We assessed risk factors for hospitalization after adjustment for age- and sex-specific prevalence of risk factors in the general Chinese population.|The median age of patients with H7N9 virus infection was older than other patient groups (63 years; P < .001) and a higher proportion was male (71%; P < .02). After adjustment for age and sex, chronic heart disease was associated with an increased risk of hospitalization with H7N9 (relative risk, 9.68; 95% confidence interval, 5.24-17.9). H7N9 patients had similar patterns of leukopenia, thrombocytopenia, and elevated alanine aminotransferase, creatinine kinase, C-reactive protein, and lactate dehydrogenase to those seen in H5N1 patients, which were all significantly different from pH1N1 patients (P < .005). H7N9 patients had a longer duration of hospitalization than either H5N1 or pH1N1 patients (P < .001), and the median time from onset to death was 18 days for H7N9 (P = .002) vs 11 days for H5N1 and 15 days for pH1N1 (P = .154).|The identification of known risk factors for severe seasonal influenza and the more protracted clinical course compared with that of H5N1 suggests that host factors are an important contributor to H7N9 severity.

Subject:

[+]

Document Type:

Journal Article

Funding:

089276/B/09/Z/Wellcome Trust/United Kingdom ; 089276/Z/09/Z/Wellcome Trust/United Kingdom ; U19 AI51915/AI/NIAID NIH HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	supp_58_8_1095__index.html	text/html
	supp_ciu053_ciu053supp.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	ciu053.nxml	text/plain
	ciu05301.gif	image/gif
	ciu05301.jpg	image/jpeg
	ciu05302.gif	image/gif
	ciu05302.jpg	image/jpeg
	license.txt	text/plain

No Related Documents.

You May Also Like:

Human Antibody Responses to Avian Influenza A(H7N9) Virus, 2013

Personal Author:

Guo, Li; Zhang, Xi; Ren, Lili; Yu, Xuelian; Chen, Lijuan; Zhou, Hongli; Gao, Xin; Teng, Zheng; Li, Jianguo; Hu, Jiayu; Wu, Chao; Xiao, Xia; Zhu, Yiyi; Wang, Quanyi; Pang, Xinghuo; Jin, Qi; Wu, Fan; Wang, Jianwei;

Published Date:

Feb 2014

Source:

Emerg Infect Dis. 20(2):192-200.

Description:

Understanding host antibody response is crucial for predicting disease severity and for vaccine development. We investigated antibody responses against influenza A(H7N9) virus in 48 serum samples from 21 patients, including paired samples from 15 pat...

File Type:

[PDF - 545.64 KB]
Human Monoclonal Antibody 81.39a Effectively Neutralizes Emerging Influenza A Viruses of Group 1 and 2 Hemagglutinins

Personal Author:

Marjuki, Henju; Mishin, Vasiliy P.; Chai, Ning; Tan, Man-Wah; Newton, Elizabeth M.; Tegeris, John; Erlandson, Karl; Willis, Melissa; Jones, Joyce; Davis, Todd; Stevens, James; Gubareva, Larisa V.;

Published Date:

Nov 14 2016

Source:

J Virol. 2016; 90(23):10446-10458.

Description:

The pandemic threat posed by emerging zoonotic influenza A viruses necessitates development of antiviral agents effective against various antigenic subtypes. Human monoclonal antibody (hMAb) targeting the hemagglutinin (HA) stalk offers a promising a...

File Type:

[PDF - 3.28 MB]
Centers for Disease Control and Prevention Influenza Division international activities fiscal years 2012 & 2013 annual report

Personal Author:

Outin-Blenman, Sajata; Kennedy, Pamela; Moen, Ann; Turner, Sharon; Cramer, Emily W.;

Corporate Authors:

National Center for Immunization and Respiratory Diseases (U.S.). Influenza Division.

Published Date:

2014

Description:

The U.S. Centers for Disease Control and Prevention’s (CDC) Influenza Division has a long history of supporting the World Health Organization (WHO) and its global network of National Influenza Centers (NIC). With limited resources, most internation...

File Type:

[PDF - 15.60 MB]
Mapping influenza transmission in the ferret model to transmission in humans

Personal Author:

Buhnerkempe, Michael G; Gostic, Katelyn; Park, Miran; Ahsan, Prianna; Belser, Jessica A; Lloyd-Smith, James O;

Published Date:

Sep 02 2015

Source:

eLife. 4.

Description:

The controversy surrounding 'gain-of-function' experiments on high-consequence avian influenza viruses has highlighted the role of ferret transmission experiments in studying the transmission potential of novel influenza strains. However, the mapping...

File Type:

[PDF - 1.69 MB]
Nanomicroarray and Multiplex Next-Generation Sequencing for Simultaneous Identification and Characterization of Influenza Viruses

Personal Author:

Zhao, Jiangqin; Ragupathy, Viswanath; Liu, Jikun; Wang, Xue; Vemula, Sai Vikram; El Mubarak, Haja Sittana; Ye, Zhiping; Landry, Marie L.; Hewlett, Indira;

Published Date:

Mar 2015

Source:

Emerg Infect Dis. 21(3):400-408.

Description:

Conventional methods for detection and discrimination of influenza viruses are time consuming and labor intensive. We developed a diagnostic platform for simultaneous identification and characterization of influenza viruses that uses a combination of...

File Type:

[PDF - 700.76 KB]