Details:

Alternative Title:
Clin Infect Dis
Publisher's site:
http://dx.doi.org/10.1093/cid/ciu053
Personal Author:
Wang, Chen ; Yu, Hongjie ; Horby, Peter W. ; Cao, Bin ; Wu, Peng ; ... More +
Wang, Chen ; Yu, Hongjie ; Horby, Peter W. ; Cao, Bin ; Wu, Peng ; Yang, Shigui ; Gao, Hainv ; Li, Hui ; Tsang, Tim K. ; Liao, Qiaohong ; Gao, Zhancheng ; Ip, Dennis K. M. ; Jia, Hongyu ; Jiang, Hui ; Liu, Bo ; Ni, Michael Y. ; Dai, Xiahong ; Liu, Fengfeng ; Van Kinh, Nguyen ; Liem, Nguyen Thanh ; Hien, Tran Tinh ; Li, Yu ; Yang, Juan ; Wu, Joseph T. ; Zheng, Yaming ; Leung, Gabriel M. ; Farrar, Jeremy J. ; Cowling, Benjamin J. ; Uyeki, Timothy M. ; Li, Lanjuan Less -
Description:
Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression of patients hospitalized with H7N9, H5N1, and 2009 pandemic H1N1 (pH1N1) virus infections.|We compared individual-level data from patients hospitalized with infection by H7N9 (n = 123), H5N1 (n = 119; 43 China, 76 Vietnam), and pH1N1 (n = 3486) viruses. We assessed risk factors for hospitalization after adjustment for age- and sex-specific prevalence of risk factors in the general Chinese population.|The median age of patients with H7N9 virus infection was older than other patient groups (63 years; P < .001) and a higher proportion was male (71%; P < .02). After adjustment for age and sex, chronic heart disease was associated with an increased risk of hospitalization with H7N9 (relative risk, 9.68; 95% confidence interval, 5.24-17.9). H7N9 patients had similar patterns of leukopenia, thrombocytopenia, and elevated alanine aminotransferase, creatinine kinase, C-reactive protein, and lactate dehydrogenase to those seen in H5N1 patients, which were all significantly different from pH1N1 patients (P < .005). H7N9 patients had a longer duration of hospitalization than either H5N1 or pH1N1 patients (P < .001), and the median time from onset to death was 18 days for H7N9 (P = .002) vs 11 days for H5N1 and 15 days for pH1N1 (P = .154).|The identification of known risk factors for severe seasonal influenza and the more protracted clinical course compared with that of H5N1 suggests that host factors are an important contributor to H7N9 severity.
Subject:
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Articles And Commentaries
Clinical Epidemiology
Influenza A(H5N1)
Influenza A(H7N9)

Source:
Clin Infect Dis. 2014; 58(8):1095-1103.
Document Type:
Journal Article
Funding:
089276/B/09/Z/Wellcome Trust/United Kingdom ; 089276/Z/09/Z/Wellcome Trust/United Kingdom ; U19 AI51915/AI/NIAID NIH HHS/United States
089276/B/09/Z/Wellcome Trust/United Kingdom ; 089276/Z/09/Z/Wellcome Trust/United Kingdom ; U19 AI51915/AI/NIAID NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:30b802058554e8bcf3b8c39ac56c3c751a5dd235e037dc5e07661517561787b2
File Type:

Supporting Files

• 	supp_58_8_1095__index.html	htm
  	supp_ciu053_ciu053supp.docx	docx
  	ciu053.nxml	txt
  	ciu05301.gif	gif
  	ciu05301.jpg	jpeg
  	ciu05302.gif	gif
  	ciu05302.jpg	jpeg
  	license.txt	txt

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