ATSDR’s Exposure-Dose Reconstruction Program program summary
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ATSDR’s Exposure-Dose Reconstruction Program program summary

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      The Agency for Toxic Substances and Disease Registry (ATSDR), a U.S. Public Health Service agency, established the Exposure-Dose Reconstruction Program (EDRP) in March 1993. Because direct measures of exposure and dose, especially historical exposures, are often unavailable to health assessors and health scientists, the agency embarked on a coordinated, comprehensive effort to develop sensitive, integrated, science-based methods for exposure-dose characterization. The agency's EDRP coordinates relevant intramural and extramural projects covering environmental, geochemical, epidemiological, and disciplines.

      For its purposes, ATSDR defines exposure-dose reconstruction as an approach that uses computational models and other approximation techniques to estimate cumulative amounts of hazardous substances internalized by persons at presumed or actual risk from contact with substances associated with hazardous waste sites. Although the emphasis of the program is on estimating past exposures, ATSDR also uses direct personal space and biologic sampling to determine current exposure levels. These direct exposure methods complement the EDRP.

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