Influenza and other respiratory virus infections in outpatients with medically attended acute respiratory infection during the 2011-12 influenza season

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  Zimmerman, Richard K. ; Rinaldo, Charles R. ; Nowalk, Mary Patricia ; GK, Balasubramani ; Thompson, Mark G. ; Moehling, Krissy K. ; Bullotta, Arlene ; Wisniewski, Stephen
• Description:
  Background ; Respiratory tract infections are a major cause of outpatient visits, yet only a portion is tested to determine the etiologic organism. Multiplex reverse transcriptase polymerase chain reaction (MRT-PCR) assays for detection of multiple viruses are being used increasingly in clinical settings. ; Methods ; During January–April 2012, outpatients with acute respiratory illness (≤7 days) were tested for influenza using singleplex RT-PCR (SRT-PCR). A subset was assayed for 18 viruses using MRT-PCR to compare detection of influenza and examine the distribution of viruses and characteristics of patients using multinomial logistic regression. ; Results ; Among 662 participants (6 months–82 years), detection of influenza was similar between the MRT-PCR and SRT-PCR (κ = 0·83). No virus was identified in 267 (40.3%) samples. Commonly detected viruses were human rhinovirus (HRV, 15·4%), coronavirus (CoV, 10·4%), respiratory syncytial virus (RSV, 8·4%), human metapneumovirus (hMPV, 8·3%), and influenza (6%). Co-detections were infrequent (6·9%) and most commonly occurred among those <18 years old. In regression analyses, compared with non-viral illnesses, RSV and hMPV were significantly more frequent in children and less frequent in 18- to 49-year-olds than in those ≥50 years (P = 0·01), fever was more common in hMPV and influenza infections (P = 0·008), nasal congestion was more frequent in CoV, HRV, hMPV, influenza and RSV infections (P = 0·001), and body mass index was higher among those with influenza (P = 0·036). ; Conclusions ; Using MRT-PCR, a viral etiology was found in three-fifths of patients with medically attended outpatient visits for acute respiratory illness during the influenza season; co-detected viruses were infrequent. Symptoms varied by viral etiology.
• Subjects:
  • Original Articles
  • Co-detection
  • influenza
  • RT-PCR
  • viral infections
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  More +
• Source:
  Influenza Other Respir Viruses. 2014; 8(4):397-405.
• Document Type:
  Journal Article
• Funding:
  UL1 RR024153/RR/NCRR NIH HHS/United States ; UL1 RR024153/RR/NCRR NIH HHS/United States ; UL1 TR000005/TR/NCATS NIH HHS/United States ; UL1TR000005/TR/NCATS NIH HHS/United States
• Volume:
  8
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/26783/cdc_26783_DS1.pdf
• File Type:
  [PDF - 173.41 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3e8edce53ef77e71b7c5d1233d45b5cc17ab83aaa4054aa8d81ced90406e4421