Stephen B. Thacker CDC Library collection

Atypical and severe manifestations -- Risk groups for severe disease -- Pregnant women and newborns -- Treatment and clinical management -- Selected references.

Atypical and severe manifestations

• Although most chikungunya virus infections result in fever and arthralgia, other clinical manifestations can occur.

• Atypical or severe clinical manifestations can be due to the direct effects of the virus, immunologic response to the virus,

drug toxicity, or diseases unrelated to chikungunya virus infection.

• Some atypical or severe manifestations are more common in certain groups. For example, vesiculobullous lesions, febrile

seizures, and meningoencephalitis have been reported in infants and young children.

• Since many atypical and severe clinical manifestations will be unrelated to chikungunya virus infection, healthcare

providers should consider and evaluate for other etiologies.