Placental Malaria Is Rare Among Zanzibari Pregnant Women Who Did Not Receive Intermittent Preventive Treatment in Pregnancy

Details

• Alternative Title:
  Am J Trop Med Hyg
• Personal Author:
  Plotkin, Marya ; Said, Khadija ; Msellem, Mwinyi I. ; Chase, Rachel P. ; Hendler, Natalie ; Khamis, Asma Ramadhan ; Roman, Elaine ; Kitojo, Chonge ; Schwartz, Alanna C. ; Gutman, Julie ; McElroy, Peter D.
• Description:
  Zanzibar has transitioned from malaria control to the pre-elimination phase, and the continued need for intermittent preventive treatment during pregnancy (IPTp) has been questioned. We conducted a prospective observational study to estimate placental malaria positivity rate among women who did not receive IPTp with sulfadoxine-pyrimethamine. A convenience sample of pregnant women was enrolled from six clinics on the day of delivery from August of 2011 to September of 2012. Dried placental blood spot specimens were analyzed by polymerase chain reaction (PCR); 9 of 1,349 specimens (0.7%; precision estimate = 0.2-1.1%) were PCR-positive for Plasmodium falciparum. Placental infection was detected on both Pemba (N = 3) and Unguja (N = 6). Placental malaria positivity in Zanzibar was low, even in the absence of IPTp. It may be reasonable for the Ministry of Health to consider discontinuing IPTp, intensifying surveillance efforts, and promoting insecticide-treated nets and effective case management of malaria in pregnancy.
• Subjects:
  Adolescent Adult Antimalarials Articles Dried Blood Spot Testing Drug Administration Schedule Drug Combinations Female Humans Malaria, Falciparum Middle Aged Placenta Plasmodium Falciparum Polymerase Chain Reaction Pregnancy Prospective Studies Pyrimethamine Sulfadoxine

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• Source:
  Am J Trop Med Hyg. 2014; 91(2):367-373.
• Document Type:
  Journal Article
• Place as Subject:
  Tanzania
• Volume:
  91
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:af16cb8c3165f16b3144303f1f77a5b18462d6b71912fb8161615119b96d568e
• Download URL:
  https://stacks.cdc.gov/view/cdc/26616/cdc_26616_DS1.pdf
• File Type:
  [PDF - 625.37 KB ]