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Candida glabrata: Multidrug Resistance and Increased Virulence in a Major Opportunistic Fungal Pathogen

Supporting Files
File Language:
English


Details

  • Alternative Title:
    Current Fungal Infection Reports, 2012, v. 6, no. 3: Candida glabrata: Multidrug Resistance and Increased Virulence in a Major Opportunistic Fungal Pathogen
  • Journal Article:
    Current Fungal Infection Reports
  • Personal Author:
    Pfaller, Michael A. ; Castanheira, Mariana ; Lockhart, Shawn R. ; Jones, Ronald N.
  • Description:
    is widely acknowledged to be an important and potentially antifungal resistant cause of hematogenously disseminated candidiasis (HDC). In the United States (US) both the frequency of

    as a cause of HDC and in vitro resistance to fluconazole has increased steadily since 1992. Although this species is generally considered to be less virulent than

    , recent findings suggest that gain of function (GOF) mutations in the transcriptional regulator CgPdr1p results not only in broad resistance to azole antifungals but also an increase in both fitness and virulence in animal models. Furthermore, case reports and case series suggest the emergence of multidrug resistance (MDR) in this species. Recent data from multicenter surveys conducted in the US have demonstrated the emergence of co-resistance to both azoles and echinocandins in clinical isolates of

    . These findings are highlighted in an effort to bring attention to this important development.
  • Content Notes:
    Author manuscript
  • Subjects:
  • Keywords:
  • Source:
    Current Fungal Infection Reports, 2012, v. 6, no. 3
  • DOI:
    https://doi.org/10.1007/s12281-012-0091-0
  • ISSN:
    1936-3761 ; 1936-377X
  • Pubmed ID:
    40093589
  • Pubmed Central ID:
    PMC11907269
  • Document Type:
    Text
  • Funding:
    CC999999/ImCDC/Intramural CDC HHSUnited States/
  • Genre:
    Journal Article
  • Pages in Document:
    154-164 (18 pdf pages)
  • Volume:
    6
  • Issue:
    3
  • Download URL:
    https://stacks.cdc.gov/view/cdc/262126/cdc_262126_DS1.pdf
  • File Type:
    Filetype[PDF - 360.57 KB]
  • Collection(s):
    CDC Public Access
  • Main Document Checksum:
    urn:sha-512:4d0cc48a587e47839f0ac54ee9297da270393f171b1c05be8d18a9c3992b8079be95a2c1c22ebe76ee441ad2c0b54493cb887390ec44936a084cd49689f8c6eb

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