High BMI Z-Scores From Different Growth References Are Not Comparable: an Example From a Weight Management Trial With an Anti-Obesity Medication in Pubertal Adolescents With Obesity.

Details

• Alternative Title:
  Childhood Obesity (Print), 2025, v. 21, no. 1: High BMI Z-Scores From Different Growth References Are Not Comparable: an Example From a Weight Management Trial With an Anti-Obesity Medication in Pubertal Adolescents With Obesity.
• Journal Article:
  Childhood Obesity (Print)
• Personal Author:
  Hales, Craig M. ; Ogden, Cynthia L. ; Freedman, David S. ; Sahu, Kushal ; Hale, Paula M. ; Mamadi, Rashmi K. ; Kelly, Aaron S.
• Description:
  The BMI z-score is a standardized measure of weight status and weight change in children and adolescents. BMI z-scores from various growth references are often considered comparable, and differences among them are underappreciated.
  
  This study reanalyzed data from a weight management clinical study of liraglutide in pubertal adolescents with obesity using growth references from CDC 2000, CDC Extended, World Health Organization (WHO), and International Obesity Task Force.
  
  BMI z-score treatment differences varied 2-fold from -0.13 (CDC 2000) to -0.26 (WHO) overall and varied almost 4-fold from -0.05 (CDC 2000) to -0.19 (WHO) among adolescents with high baseline BMI z-score.
  
  Depending upon the growth reference used, BMI z-score endpoints can produce highly variable treatment estimates and alter interpretations of clinical meaningfulness. BMI z-scores cited without the associated growth reference cannot be accurately interpreted.
• Content Notes:
  Author manuscript
• Subjects:
  • Secondary Data Analysis
  • Body Mass Index
  • Reference Values
  • Randomized Controlled Trials as Topic
  • Clinical Trials, Phase III as Topic
  • Humans
  • Male
  • Female
  • Adolescent
  • Multicenter Studies as Topic
  More +
• Keywords:
  • BMI
  • childhood obesity
  • clinical endpoints
  • clinical trials
  • growth chart
  • growth reference
• Source:
  Childhood Obesity (Print), 2025, v. 21, no. 1
• DOI:
  https://doi.org/10.1089/chi.2024.0248
• ISSN:
  2153-2168 ; 2153-2176
• Pubmed ID:
  38995874
• Pubmed Central ID:
  PMC12422332
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  22-29 (14 pdf pages)
• Volume:
  21
• Issue:
  1
• Download URL:
  https://stacks.cdc.gov/view/cdc/262081/cdc_262081_DS1.pdf
• File Type:
  [PDF - 1.13 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:06ecbe4a7d1a26a4b34a70e2651bbe1c81c90c8cb07fdc21c6ea191d93debeedaefc305336429f786a4bbc1aa57acfaf7d9fc9b62c16f2956508b08263872966