An Accelerated PETALUTE MRI Sequence For in Vivo Quantification of Sodium Content in Human Articular Cartilage at 3T.

Details

• Alternative Title:
  Skeletal Radiology, 2025, v. 54, no. 3: An Accelerated PETALUTE MRI Sequence For in Vivo Quantification of Sodium Content in Human Articular Cartilage at 3T.
• Journal Article:
  Skeletal Radiology
• Personal Author:
  Villarreal, Cameron X. ; Shen, Xin ; Alhulail, Ahmad A. ; Buffo, Nicholas M. ; Zhou, Xiaopeng ; Pogue, Evan ; Özen, Ali Caglar ; Chiew, Mark ; Sawiak, Stephen ; Emir, Uzay ; Chan, Deva D.
• Description:
  In this work, we evaluate the sodium magnetic resonance imaging (MRI) capabilities of a three-dimensional (3D) dual-echo ultrashort echo time (UTE) sequence with a novel rosette petal trajectory (PETALUTE), in comparison to the 3D density-adapted (DA) radial spokes UTE sequence in human articular cartilage in the knee.
  
  We scanned five healthy subjects using a 3D dual-echo PETALUTE acquisition and two comparable implementations of 3D DA-radial spokes acquisitions, one matching the number of k-space projections (Radial - Matched Spokes) and the other matching the total number of samples (Radial - Matched Samples) acquired in k-space.
  
  The PETALUTE acquisition enabled equivalent sodium quantification in articular cartilage volumes of interest (168.8 ± 29.9 mM, mean ± standard deviation) to those derived from the 3D radial acquisitions (171.62 ± 28.7 mM and 149.8 ± 22.2 mM, respectively). We achieved a 41% shorter scan time of 2:06 for 3D PETALUTE, compared to 3:36 for 3D radial acquisitions. We also evaluated the feasibility of further acceleration of the PETALUTE sequence through retrospective compressed sensing with 2 × and 4 × acceleration of the first echo and showed structural similarity of 0.89 ± 0.03 and 0.87 ± 0.03 when compared to non-retrospectively accelerated reconstruction.
  
  We demonstrate improved scan time with equivalent performance using a 3D dual-echo PETALUTE sequence compared to the 3D DA-radial sequence for sodium MRI of articular cartilage.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Male
  • Female
  • Adolescent
  • Young Adult
  • Adult
  • Healthy Volunteers
  • Cartilage, Articular
  • Sodium
  • Magnetic Resonance Imaging
  More +
• Keywords:
  • Sodium MRI
  • Ultrashort echo time
  • Fixed charge density
  • Articular cartilage
• Source:
  Skeletal Radiology, 2025, v. 54, no. 3
• DOI:
  https://doi.org/10.1007/s00256-024-04774-5
• ISSN:
  0364-2348 ; 1432-2161
• Pubmed ID:
  39153083
• Pubmed Central ID:
  PMC11769871
• Document Type:
  Text
• Funding:
  S10 OD012336/OD/NIH HHSUnited States/ ; T32 DK101001/DK/NIDDK NIH HHSUnited States/ ; 2149946/Division of Civil, Mechanical and Manufacturing Innovation/ ; S10 OD012336/CD/ODCDC CDC HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  601-610 (17 pdf pages)
• Volume:
  54
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/262050/cdc_262050_DS1.pdf
• File Type:
  [PDF - 1.69 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:b46b240833578f4e6ae15f031363ab0126370d1e9ef1e7c57f1fccb1577310d9a4ee02d22a983e44a24b7c5fa6d11fd3d9e0ea5a445016144cc3086fbe977454