Observed Prevalence of Congenital Situs Inversus in the United States Before and During the SARS-CoV-2 Pandemic, 2017-2022.

Details

• Alternative Title:
  Birth Defects Research, 2024, v. 116, no. 12: Observed Prevalence of Congenital Situs Inversus in the United States Before and During the SARS-CoV-2 Pandemic, 2017-2022.
• Journal Article:
  Birth Defects Research
• Personal Author:
  Cragan, Janet D. ; Cho, Sook-Ja ; Forestieri, Nina ; Hort, Michele ; Nestoridi, Eirini ; Moore, Cynthia A. ; Stallings, Erin ; Gray, Elizabeth B. ; Reefhuis, Jennita
• Description:
  Reports from China describe an increase in the frequency of fetal situs inversus in 2023 after the country's "zero-Covid" policy was lifted, suggesting an association with maternal SARS-CoV-2 infection. However, a report of birth defects surveillance data from Scandinavia observed no sustained increase during the SARS-CoV-2 pandemic (2020-2022 vs. 2018-2019). We examined birth defects surveillance data to assess any increase in situs inversus in the U.S. during the SARS-CoV-2 pandemic.
  
  We combined data from four population-based birth defects programs in Massachusetts, Minnesota, North Carolina, and Atlanta, Georgia, to compare the prevalence of situs inversus among infants and fetuses delivered before (2017-2019) and during (2021-2022) the SARS-CoV-2 pandemic. We defined situs inversus as mirror-image transposition of the heart and/or other organs, or primary ciliary dyskinesis with situs inversus, excluding isolated dextrocardia. The programs varied in the pregnancy outcomes included (live births ± non-live births); all included both prenatal and postnatal diagnoses.
  
  We identified 294 infants and fetuses with situs inversus (6.8% non-live births). We estimated the combined prevalence per 10,000 live births as 1.72 during the pandemic versus 1.71 before the pandemic (OR = 1.005; 95% CI: 0.778-1.297). The estimated annual prevalence ranged from 1.41 in 2017 to 2.21 in 2019 with no significant trend across the study period (p = 0.39).
  
  We did not observe an increase in situs inversus during the SARS-CoV-2 pandemic. Because information about SARS-CoV-2 infection among individual pregnancies was not available from all programs, we could not assess a specific association with maternal infection.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • COVID-19
  • Situs Inversus
  • Female
  • Prevalence
  • Pregnancy
  • SARS-CoV-2
  • Infant, Newborn
  • Pandemics
  • Pregnancy Complications, Infectious
  More +
• Keywords:
  • birth defect
  • COVID-19
  • laterality
  • pandemic
  • prevalence
  • SARS-CoV-2
  • situs inversus
• Source:
  Birth Defects Research, 2024, v. 116, no. 12
• DOI:
  https://doi.org/10.1002/bdr2.2424
• ISSN:
  2472-1727
• Pubmed ID:
  39665216
• Pubmed Central ID:
  PMC11812594
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  e2424 (8 pdf pages)
• Volume:
  116
• Issue:
  12
• Download URL:
  https://stacks.cdc.gov/view/cdc/261860/cdc_261860_DS1.pdf
• File Type:
  [PDF - 477.40 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:aeab9ecac33518e9458774d5ced5ae9d24d773af858b5e3ff679f9615c24385674a3e1221af4c4c084f595b8d71bc062f3f3eb948aec8605bc9ea1c3e09d42cd