The Monogenic Landscape of Human Infectious Diseases.

Details

• Alternative Title:
  The Journal of Allergy and Clinical Immunology, 2025, v. 155, no. 3: The Monogenic Landscape of Human Infectious Diseases.
• Journal Article:
  The Journal of Allergy and Clinical Immunology
• Personal Author:
  Boisson-Dupuis, Stéphanie ; Bastard, Paul ; Béziat, Vivien ; Bustamante, Jacinta ; Cobat, Aurélie ; Jouanguy, Emmanuelle ; Puel, Anne ; Rosain, Jérémie ; Zhang, Qian ; Zhang, Shen-Ying ; Boisson, Bertrand
• Description:
  The spectrum of known monogenic inborn errors of immunity is growing, with certain disorders underlying a specific and narrow range of infectious diseases. These disorders reveal the core mechanisms by which these infections occur in various settings, including inherited and acquired immunodeficiencies, thereby delineating the essential mechanisms of protective immunity to the corresponding pathogens. These findings also have medical implications, facilitating diagnosis and improving the management of individuals at risk of disease.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Communicable Diseases
  • Immunologic Deficiency Syndromes
  • Animals
• Keywords:
  • Mendelian and monogenic infections
  • Inborn errors of immunity
  • protection against common pathogens
  • infections
• Source:
  The Journal of Allergy and Clinical Immunology, 2025, v. 155, no. 3
• DOI:
  https://doi.org/10.1016/j.jaci.2024.12.1078
• ISSN:
  0091-6749 ; 1097-6825
• Pubmed ID:
  39724971
• Pubmed Central ID:
  PMC11875930
• Document Type:
  Text
• Funding:
  R01 NS072381/NS/NINDS NIH HHSUnited States/ ; R01 AI095983/AI/NIAID NIH HHSUnited States/ ; R21 AI151663/AI/NIAID NIH HHSUnited States/ ; UL1 TR001866/TR/NCATS NIH HHSUnited States/ ; R01 AI143810/AI/NIAID NIH HHSUnited States/ ; U19 AI162568/AI/NIAID NIH HHSUnited States/ ; U17 CE001236/CE/NCIPC CDC HHSUnited States/ ; R01 AI088364/AI/NIAID NIH HHSUnited States/ ; R01 AI127564/AI/NIAID NIH HHSUnited States/ ; R01 AI163029/AI/NIAID NIH HHSUnited States/ ; R21 AI159728/AI/NIAID NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  768-783 (34 pdf pages)
• Volume:
  155
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/261823/cdc_261823_DS1.pdf
• File Type:
  [PDF - 1.14 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:62a9f443322eb1ca5a01338157198604369b3c92f970e042e9e53bc8532a0cdfce848cd85b88b5c5eca7a711454e3c0ce2933a9cb6f6ac871302511b9182dab1