Breaking Research Silos to Achieve Equitable Precision Medicine in Rheumatology.

Details

• Alternative Title:
  Nature Reviews. Rheumatology, 2025, v. 21, no. 2: Breaking Research Silos to Achieve Equitable Precision Medicine in Rheumatology.
• Journal Article:
  Nature Reviews. Rheumatology
• Personal Author:
  Ainsworth, Hannah C. ; Frost, DeAnna Baker ; Lim, S. Sam ; Ramos, Paula S.
• Description:
  Health disparities in rheumatic disease are well established and urgently need addressing. Obstacles to precision medicine equity span both the clinical and the research domains, with a focus placed on structural barriers limiting equitable health care access and inclusivity in research. Less articulated factors include the use of inaccurate population descriptors and the existence of research silos in rheumatology research, which creates a knowledge gap that precludes addressing the health disparities and fulfilling the goals of precision medicine to understand the 'full patient'. The biopsychosocial model is a research framework that intertwines layers of biological and environmental effects to understand disease. However, very limited rheumatology research bridges across molecular and epidemiological studies of environmental exposures, such as physical and social determinants of health. In this Review, we discuss clinical obstacles to health care equity, including access to health care and the use of inaccurate language when labelling population groups. We explore the goals and data needed for research under the biopsychosocial model. We describe results from a rheumatic disease literature search that highlights the paucity of studies investigating the molecular influences of systemic exposures. We conclude with a list of considerations and recommendations to help achieve equitable precision medicine.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Precision Medicine
  • Rheumatology
  • Rheumatic Diseases
  • Healthcare Disparities
  • Health Services Accessibility
  • Health Equity
  • Biomedical Research
• Source:
  Nature Reviews. Rheumatology, 2025, v. 21, no. 2
• DOI:
  https://doi.org/10.1038/s41584-024-01204-7
• ISSN:
  1759-4790 ; 1759-4804
• Pubmed ID:
  39794514
• Pubmed Central ID:
  PMC11910143
• Document Type:
  Text
• Funding:
  U01 DP006698/DP/NCCDPHP CDC HHSUnited States/ ; P30 AR072582/AR/NIAMS NIH HHSUnited States/ ; K08 AR078372/AR/NIAMS NIH HHSUnited States/ ; R21 AR084039/AR/NIAMS NIH HHSUnited States/ ; R01 MD015395/MD/NIMHD NIH HHSUnited States/
• Genre:
  Journal Article
• Pages in Document:
  98-110 (29 pdf pages)
• Volume:
  21
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/261784/cdc_261784_DS1.pdf
• File Type:
  [PDF - 1.44 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:0aba0ce061335e2fd22f921c55610af76c1c7e52388f7f3a2329750945613696eaa82f05eac61918399b96da68c55d6bd0ec5e294bbc3a66c5bfe4edfbe87e3d