Patterns in Prescribing and Dispensing Influenza Antivirals Among Adults With Influenza Presenting to Urgent Care and Emergency Department Settings: VISION Network, 2023-2024.

Details

• Alternative Title:
  Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 2025, v. 81, no. 4: Patterns in Prescribing and Dispensing Influenza Antivirals Among Adults With Influenza Presenting to Urgent Care and Emergency Department Settings: VISION Network, 2023-2024.
• Journal Article:
  Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America
• Personal Author:
  Adams, Katherine ; Garg, Shikha ; Tartof, Sara Y. ; Irving, Stephanie A. ; DeSilva, Malini B. ; Klein, Nicola P. ; Natarajan, Karthik ; Dascomb, Kristin ; Grannis, Shaun J. ; Ong, Toan C. ; Salas, S. Bianca ; Sy, Lina S. ; Lewin, Bruno ; Qian, Lei ; Naleway, Allison L. ; Koppolu, Padma D. ; McEvoy, Charlene E. ; Akinsete, Omobosola ; Essien, Inih ; Fireman, Bruce ; Zerbo, Ousseny ; Jacobson, Karen B. ; Timbol, Julius ; Neelam, Varsha ; Reeves, Emily L. ; Dickerson, Monica ; Ray, Caitlin ; Link-Gelles, Ruth ; Mak, Josephine ; Ball, Sarah W. ; O'Reilly, Michael ; Olsen, Sonja J. ; Tenforde, Mark W.
• Description:
  We describe prescribing and dispensing patterns of influenza antivirals among patients with laboratory-confirmed influenza within US urgent care and emergency department settings.
  
  A retrospective cross-sectional study was conducted for encounters from 4 large, integrated health systems participating in the VIrtual Sars-cov-2, Influenza, and Other respiratory viruses Network (VISION) of adult patients presenting with acute respiratory illness to urgent care or emergency departments and with positive influenza virus test results during the 2023-2024 influenza season. The analysis was restricted to adult patients at higher risk of influenza complications based on presence of underlying medical conditions, older age, pregnancy, and severe obesity. We calculated proportions and odds of prescribed and dispensed antivirals by demographic and clinical characteristics.
  
  A total of 10 700 patient encounters were eligible for analysis. Among encounters with a positive standard molecular influenza test result (n = 5231), 58% (range across sites: 47%-64%) were prescribed antivirals, with 67% of prescribing occurring on the encounter date. Among those prescribed antivirals (n = 3050), 80% (range across sites: 75%-91%) had them dispensed, with 65% of dispensing occurring on the prescription date. Encounters among persons aged ≥65 years had lower odds of same-day prescribing (.57; 95% CI: .42-.78) and lower odds of same-day dispensing (.58; 95% CI: .36-.94) compared with those aged 18-49 years.
  
  Gaps in antiviral treatment within urgent care and emergency department settings remain for patients at higher risk of influenza complications, notably among older adults. Strategies to improve earlier initiation of antiviral treatment may help reduce the risk of influenza-associated complications.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Influenza, Human
  • Antiviral Agents
  • Female
  • Male
  • Middle Aged
  • Emergency Service, Hospital
  • Retrospective Studies
  • Adult
  • Cross-Sectional Studies
  More +
• Keywords:
  • influenza
  • antivirals
  • oseltamivir
  • prescribing
  • dispensing
• Source:
  Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America, 2025, v. 81, no. 4
• DOI:
  https://doi.org/10.1093/cid/ciaf178
• ISSN:
  1058-4838 ; 1537-6591
• Pubmed ID:
  40184184
• Pubmed Central ID:
  PMC12353082
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 AI168373/AI/NIAID NIH HHSUnited States/ ; 75D30121D12779/Centers for Disease Control and Prevention (CDC;/ ; 75D30123C17595/Centers for Disease Control and Prevention (CDC;/ ; 75D30123C18039/Centers for Disease Control and Prevention (CDC;/ ; Kaiser Foundation Hospitals/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  e172-e183 (23 pdf pages)
• Volume:
  81
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/261514/cdc_261514_DS1.pdf
• File Type:
  [PDF - 753.49 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:42d26044bf474c173e6184c1713054fb816df489c220572d674e7836b02af88fb34dee253ba6f4587191c224f866438dd4097038ac6ba4fe27d91972d9575831