Association Between Maternal Periconceptional Dietary Patterns and Occurrence of Orofacial Clefts.

Details

• Alternative Title:
  American Journal of Epidemiology, 2025, v. 194, no. 11: Association Between Maternal Periconceptional Dietary Patterns and Occurrence of Orofacial Clefts.
• Journal Article:
  American Journal of Epidemiology
• Personal Author:
  Sley, Erin G. ; Desrosiers, Tania A. ; Sotres-Alvarez, Daniela ; Carmichael, Suzan L. ; Maselko, Joanna ; Wood, Mollie E. ; Ailes, Elizabeth C. ; Nembhard, Wendy N. ; Yang, Wei ; Olshan, Andrew F.
• Corporate Authors:
  The National Birth Defects Prevention Study
• Description:
  Orofacial clefts (OFC) are a common birth defect with few known risk factors (eg, smoking). Maternal diet is associated with birth defects, though the relationship with OFC is less clear as studies typically only investigate single nutrients. We assessed the association between periconceptional maternal diet and OFC in the United States, using the National Birth Defects Prevention Study (1997-2011), including 3649 cases (2480 cleft lip with/without palate CL/P and 1169 cleft palate CP) and 10 584 controls (infants without a birth defect). Using latent class analysis, we derived dietary patterns based on relative consumption of self-reported food items via food frequency data. We used logistic regression to estimate adjusted odds ratios (aORs) and 95% CIs for the effect of dietary patterns on OFC. Four patterns were identified: Prudent (reference), Western, Low-Calorie Western, and Mexican. The Western diet had increased odds of CL/P (aOR: 1.3 95% CI, 1.2-1.5) and CP (aOR: 1.2 95% CI, 1.1-1.4). Low-Calorie Western (CL/P aOR: 1.2 95% CI, 1.0-1.4; CP aOR: 1.0 95% CI, 0.9-1.2) and Mexican diets (CL/P aOR: 1.1 95% CI, 0.9-1.3; CP aOR: 0.8 95% CI, 0.6-1.1) had a weaker or null association. Findings underscore the importance of further investigation into the effect of periconceptional diet on OFC occurrence.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Female
  • Cleft Palate
  • Cleft Lip
  • Adult
  • Pregnancy
  • Diet
  • Risk Factors
  • Case-Control Studies
  • Logistic Models
  More +
• Keywords:
  • orofacial clefts
  • maternal diet
  • dietary exposures
  • preconception
  • birth defects
  • maternal health
  • dietary patterns
  • pregnancy
• Source:
  American Journal of Epidemiology, 2025, v. 194, no. 11
• DOI:
  https://doi.org/10.1093/aje/kwaf102
• ISSN:
  0002-9262 ; 1476-6256
• Pubmed ID:
  40391741
• Pubmed Central ID:
  PMC12990157
• Document Type:
  Text
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01 DD001306/DD/NCBDD CDC HHSUnited States/ ; Centers for Disease Control and Prevention (CDC) to the North Carolina Center for Birth Defects Research/ ; U01DD001231/Prevention at the University of North Carolina at Chapel Hill/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  3217-3228 (21 pdf pages)
• Volume:
  194
• Issue:
  11
• Download URL:
  https://stacks.cdc.gov/view/cdc/261404/cdc_261404_DS1.pdf
• File Type:
  [PDF - 2.28 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:4b201ffede1cb14e985f9fbb22a512d104aa642a6898c5d30dae2911360387b6ea8127d213a86bdfdbf6b8ce665e23692cbba4f46273d2f3cfa74f041a893499