Associations of Age at T2D Detection With Hemoglobin A1c in a National Inception Cohort of U.S. Veterans With Diabetes.

Details

• Alternative Title:
  Diabetes Research and Clinical Practice, 2025, v. 226: Associations of Age at T2D Detection With Hemoglobin A1c in a National Inception Cohort of U.S. Veterans With Diabetes.
• Journal Article:
  Diabetes Research and Clinical Practice
• Personal Author:
  Avramovic, Sanja ; Li, Xumin ; Enquobahrie, Daniel A. ; Schwartz, Mark D. ; Korpak, Anna ; Boyko, Edward J. ; Wander, Pandora L.
• Description:
  To investigate associations of age at type 2 diabetes (T2D) detection with HbA1c.
  
  We examined associations of early-onset T2D (age of detection 20-39 years) and age at T2D detection with HbA1c in Veterans with incident T2D (1/1/2008-12/31/2016; n = 851,302).
  
  About 3 % (n = 22,649) of men and 11 % (n = 5,117) of women had early-onset T2D. Compared to men with later-onset T2D, men with early-onset T2D had a 0.71 (95 %CI 0.69,0.73) greater HbA1c after detection, a 0.78 (95 %CI 0.77,0.80) greater mean HbA1c, and a 0.05 (95 %CI 0.04,0.05) greater coefficient of variation (CV). Each 10-year decrease in age was associated with greater HbA1c after detection, mean HbA1c, and HbA1c CV (β 0.21 (95 %CI 0.21,0.21), 0.25 (95 %CI 0.24,0.25), 0.02 (95 %CI 0.02,0.02), respectively). In women, early-onset T2D was associated with a 0.14 (95 %CI -0.18,-0.10) lower HbA1c after detection and a 0.01 greater CV (95 %CI 0.01,0.01). Each ten-year decrease in age was associated with greater mean HbA1c and CV (β 0.09 (95 %CI 0.08,0.10); 0.01 (95 %CI 0.01,0.01), respectively).
  
  Among male Veterans, early-onset T2D was associated with greater HbA1c and greater HbA1c variability. Similar results were seen among women but of lesser magnitude. Longitudinal research examining sex-specific impacts of early-onset T2D on clinical course is needed.
• Content Notes:
  Author manuscript
• Subjects:
  • Humans
  • Glycated Hemoglobin
  • Male
  • Diabetes Mellitus, Type 2
  • Female
  • Veterans
  • Adult
  • Middle Aged
  • Age of Onset
  • Young Adult
  More +
• Source:
  Diabetes Research and Clinical Practice, 2025, v. 226
• DOI:
  https://doi.org/10.1016/j.diabres.2025.112332
• ISSN:
  0168-8227 ; 1872-8227
• Pubmed ID:
  40545148
• Pubmed Central ID:
  PMC12317824
• Document Type:
  Text
• Funding:
  U01 DP006299/DP/NCCDPHP CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  112332 (14 pdf pages)
• Volume:
  226
• Download URL:
  https://stacks.cdc.gov/view/cdc/261313/cdc_261313_DS1.pdf
• File Type:
  [PDF - 573.69 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f5c91350243964064753157617a25251736ba14111b774f0cc5953de6c4e4060e7ee88b60e738fa4700c880f79e308579917cd421b6bef0468ed96082b45485f