Improving pandemic influenza risk assessment

Details

• Alternative Title:
  eLife
• Personal Author:
  Russell, Colin A ; Kasson, Peter M ; Donis, Ruben O ; Riley, Steven ; Dunbar, John ; Rambaut, Andrew ; Asher, Jason ; Burke, Stephen ; Davis, C Todd ; Garten, Rebecca J ; Gnanakaran, Sandrasegaram ; Hay, Simon I ; Herfst, Sander ; Lewis, Nicola S ; Lloyd-Smith, James O ; Macken, Catherine A ; Maurer-Stroh, Sebastian ; Neuhaus, Elizabeth ; Parrish, Colin R ; Pepin, Kim M ; Shepard, Samuel S ; Smith, David L ; Suarez, David L ; Trock, Susan C ; Widdowson, Marc-Alain ; George, Dylan B ; Lipsitch, Marc ; Bloom, Jesse D
• Description:
  Assessing the pandemic risk posed by specific non-human influenza A viruses is an important goal in public health research. As influenza virus genome sequencing becomes cheaper, faster, and more readily available, the ability to predict pandemic potential from sequence data could transform pandemic influenza risk assessment capabilities. However, the complexities of the relationships between virus genotype and phenotype make such predictions extremely difficult. The integration of experimental work, computational tool development, and analysis of evolutionary pathways, together with refinements to influenza surveillance, has the potential to transform our ability to assess the risks posed to humans by non-human influenza viruses and lead to improved pandemic preparedness and response.
• Subjects:
  Base Sequence Biological Evolution Emergence Epidemiological Monitoring Feature Article Genomics And Evolutionary Biology Geography Human Humans Influenza Influenza, Human Influenza A Virus Microbiology And Infectious Disease Models, Biological Pandemic Pandemics Public Health Risk Assessment Science Forum Viruses

  More +
• Source:
  eLife. 3
• Pubmed ID:
  25321142
• Pubmed Central ID:
  PMC4199076
• Document Type:
  Journal Article
• Funding:
  U01 GM110721/GM/NIGMS NIH HHS/United States ; 095066/Wellcome Trust/United Kingdom ; R01 GM098304/GM/NIGMS NIH HHS/United States ; MR/J008761/1/Medical Research Council/United Kingdom ; MR/K010174/1/Medical Research Council/United Kingdom ; 095831/Wellcome Trust/United Kingdom ; R01 GM102198/GM/NIGMS NIH HHS/United States
• Volume:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f7d5bff66cbbe3555b99b8375200d51df3d9c99d97733fd2ad7727ca96b45330
• Download URL:
  https://stacks.cdc.gov/view/cdc/26075/cdc_26075_DS1.pdf
• File Type:
  [PDF - 7.63 MB ]